EG626305 Inhibitors
Scgb1b7, a member of the secretoglobin family, exhibits a predicted functionality in steroid binding activity and is active within the extracellular region. This protein likely plays a crucial role in modulating cellular responses to steroids, participating in signaling cascades that regulate various physiological processes. The steroid binding activity of Scgb1b7 suggests its involvement in the intricate network of molecular interactions that govern steroid metabolism, signaling, and cellular communication. Its localization in the extracellular region further implies its potential role in mediating extracellular signaling events, possibly through interactions with other proteins or cell surface receptors. In the context of inhibition, various chemical agents have been identified as potential modulators of Scgb1b7 function. These inhibitors act through diverse mechanisms, either directly interacting with the protein or influencing key cellular pathways associated with its activity. For instance, glucocorticoid receptor agonists, such as Budesonide, directly inhibit Scgb1b7 by binding to the glucocorticoid receptor, disrupting its steroid binding activity and altering extracellular region activation.
Similarly, androgen receptor antagonists like Flutamide interfere with Scgb1b7 function by modulating steroid binding activity, providing a specific mechanism of inhibition. Indirect inhibitors, such as those affecting steroid biosynthesis or hormone levels, influence Scgb1b7 function by altering the cellular milieu in which it operates. This includes agents like Aminoglutethimide, which inhibits aromatase, impacting steroid biosynthesis and indirectly affecting Scgb1b7. Understanding the function and inhibition of Scgb1b7 is integral to unraveling the intricacies of steroid-related processes within the cellular context. The diverse array of inhibitors elucidates the multifaceted nature of the regulatory mechanisms governing Scgb1b7, emphasizing the interconnectedness of steroid signaling pathways and extracellular interactions. These insights into Scgb1b7's function and inhibition contribute to the broader comprehension of molecular processes underlying steroid biology, paving the way for more targeted investigations into the intricate world of secretoglobin-mediated cellular responses to steroids.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Budesonide | 51333-22-3 | sc-202980 sc-202980A sc-202980B sc-202980C | 50 mg 100 mg 200 mg 500 mg | $77.00 $88.00 $151.00 $343.00 | 3 | |
Budesonide is a glucocorticoid receptor agonist with a potent anti-inflammatory effect. It directly inhibits Scgb1b7 by binding to the glucocorticoid receptor, altering the steroid binding activity and extracellular region activation, thereby downregulating the gene expression. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole, an antifungal agent, indirectly inhibits Scgb1b7 by disrupting the CYP450 enzymes involved in steroid metabolism. This alteration in steroid metabolism influences the gene's activity, hindering steroid binding and extracellular region function. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $46.00 $153.00 $168.00 $515.00 $923.00 | 4 | |
As an androgen receptor antagonist, flutamide directly inhibits Scgb1b7 by modulating steroid binding activity. It interferes with androgen signaling pathways, affecting the gene's activity in the extracellular region. | ||||||
Trilostane | 13647-35-3 | sc-208469 sc-208469A | 10 mg 100 mg | $224.00 $1193.00 | 2 | |
Trilostane is an inhibitor of 3-beta-hydroxysteroid dehydrogenase, a key enzyme in steroid biosynthesis. By inhibiting this enzyme, trilostane indirectly affects Scgb1b7, leading to altered steroid levels and subsequent modulation of the gene's activity in steroid binding and the extracellular region. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $60.00 | 17 | |
Mifepristone, a progesterone receptor antagonist, directly inhibits Scgb1b7 by interfering with steroid binding activity. Its action on the progesterone receptor alters the gene's function in the extracellular region, providing a specific inhibition mechanism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, an isothiocyanate compound, indirectly inhibits Scgb1b7 by activating Nrf2 signaling. This leads to the upregulation of antioxidant response elements, influencing the gene's activity in the extracellular region and steroid binding through redox modulation. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $240.00 $1030.00 | 7 | |
MDV3100 is an androgen receptor inhibitor that directly targets Scgb1b7, modulating steroid binding activity. By interfering with androgen signaling, it influences the gene's function in the extracellular region, providing a specific mechanism of inhibition. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $41.00 $143.00 $530.00 $2020.00 | 2 | |
Aminoglutethimide inhibits aromatase, an enzyme involved in steroid biosynthesis. This indirect inhibition affects Scgb1b7 by altering steroid levels, influencing its steroid binding activity and function in the extracellular region. | ||||||
Abiraterone Acetate | 154229-18-2 | sc-207240 | 5 mg | $231.00 | 1 | |
Abiraterone acetate inhibits CYP17, a key enzyme in androgen biosynthesis. By blocking androgen production, it directly inhibits Scgb1b7, affecting steroid binding activity and the gene's function in the extracellular region. | ||||||
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $71.00 $163.00 | 1 | |
Mitotane, an adrenolytic agent, indirectly inhibits Scgb1b7 by disrupting steroid production in the adrenal cortex. This alteration in steroid levels influences the gene's activity in steroid binding and the extracellular region. | ||||||