EG623459 Activators
Faiml, a Fas apoptotic inhibitory molecule-like protein, exhibits a multifaceted role in cellular processes, primarily associated with I-kappaB kinase (IKK)/NF-kappaB signaling, negative regulation of extrinsic apoptotic signaling pathways via death domain receptors, and positive regulation of neurogenesis. Its activation is crucial for maintaining cellular homeostasis and regulating key signaling pathways involved in cell survival and differentiation. Activation of Faiml involves a complex interplay of chemicals that modulate specific signaling pathways. In the context of IKK/NF-kappaB signaling, chemicals like BAY 11-7082, Celastrol, 6-Aminoquinoline, Withaferin A, Parthenolide, and JSH-23 play pivotal roles. BAY 11-7082 inhibits IKK, preventing NF-kappaB activation, while Celastrol, 6-Aminoquinoline, Withaferin A, Parthenolide, and JSH-23 modulate NF-kappaB signaling, potentially leading to the up-regulation of Faiml expression.
In the realm of neurogenesis, chemicals like Dorsomorphin, LDN-193189, Rolipram, LY364947, NSC 23766, and SB203580 exert their influence. Dorsomorphin and LDN-193189 inhibit BMP and TGF-beta signaling, respectively, impacting Faiml expression and its role in neurogenesis. Rolipram elevates cAMP levels, potentially influencing Faiml expression and neurogenesis. LY364947 and NSC 23766 modulate TGF-beta and Rac1 signaling, respectively, impacting Faiml's involvement in the negative regulation of apoptotic signaling pathways via death domain receptors. In summary, Faiml, with its diverse functional roles, relies on the modulation of IKK/NF-kappaB signaling, regulation of apoptotic pathways, and control of neurogenesis for proper cellular function. The activation of Faiml is intricately connected to the modulation of specific signaling pathways, ensuring its involvement in cellular processes critical for cell survival and differentiation. The fine-tuned orchestration of these pathways highlights the importance of Faiml in cellular homeostasis and its potential as a key player in strategies targeting these pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Inhibitor of I-kappaB kinase (IKK). Indirectly activates Faiml by preventing the degradation of I-kappaB, inhibiting NF-kappaB signaling, and potentially leading to the up-regulation of Faiml expression in the cell. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Modulates NF-kappaB signaling. Indirectly influences Faiml by inhibiting the activation of NF-kappaB, potentially up-regulating Faiml expression and affecting its involvement in I-kappaB kinase (IKK)/NF-kappaB signaling. | ||||||
6-Aminoquinoline | 580-15-4 | sc-239088 | 1 g | $49.00 | ||
Activator of NF-kappaB. Indirectly stimulates Faiml by promoting NF-kappaB signaling, potentially influencing Faiml expression in the context of I-kappaB kinase (IKK)/NF-kappaB signaling. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Modulates NF-kappaB signaling. Indirectly influences Faiml by inhibiting NF-kappaB activation, potentially leading to the up-regulation of Faiml expression and affecting its involvement in I-kappaB kinase (IKK)/NF-kappaB signaling. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Inhibitor of NF-kappaB. Indirectly activates Faiml by suppressing NF-kappaB signaling, potentially leading to the up-regulation of Faiml expression in the context of I-kappaB kinase (IKK)/NF-kappaB signaling. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
Inhibitor of NF-kappaB nuclear translocation. Indirectly influences Faiml by preventing the nuclear translocation of NF-kappaB, potentially leading to the up-regulation of Faiml expression and affecting its involvement in I-kappaB kinase (IKK)/NF-kappaB signaling. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $182.00 $736.00 | 28 | |
Inhibitor of BMP signaling. Indirectly stimulates Faiml by inhibiting BMP signaling, potentially influencing Faiml expression and its involvement in neurogenesis. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
BMP receptor inhibitor. Indirectly influences Faiml by blocking BMP signaling, potentially impacting Faiml expression and its role in the regulation of neurogenesis. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Phosphodiesterase 4 (PDE4) inhibitor. Indirectly activates Faiml by elevating cAMP levels, potentially influencing Faiml expression and its involvement in neurogenesis. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
TGF-beta receptor inhibitor. Indirectly stimulates Faiml by blocking TGF-beta signaling, potentially impacting Faiml expression and its involvement in the negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. | ||||||