EG546400 Inhibitors
Claudin 34B1, encoded by the Cldn34b1 gene, is implicated in essential cellular processes related to bicellular tight junction assembly and cell adhesion. Within the cellular landscape, this protein is predicted to exert its influence primarily at the plasma membrane and tight junctions. The tight junctions, critical structures in cell biology, are pivotal for maintaining the integrity of epithelial and endothelial barriers. These structures not only facilitate cell-cell adhesion but also regulate the passage of ions, molecules, and cells across epithelial layers. Given Cldn34b1's predicted involvement in bicellular tight junction assembly, it emerges as a key player in the orchestration of these cellular junctions, contributing to the overall cellular architecture. In exploring the potential avenues for inhibiting Cldn34b1, various chemical compounds emerge as candidates influencing specific cellular pathways. Calcium channel blockers, for instance, disrupt tight junction assembly by interfering with calcium signaling, a crucial regulator of junction dynamics. Rho-associated kinase (ROCK) inhibitors alter actin cytoskeleton dynamics, indirectly impacting Cldn34b1 by impairing tight junction assembly. Protein kinase C (PKC) inhibitors modulate signaling pathways affecting tight junction organization, contributing to the impairment of Cldn34b1 function. Inhibition of myosin light chain kinase (MLCK) disrupts actin cytoskeleton dynamics, indirectly influencing Cldn34b1 by impairing tight junction assembly. Additionally, compounds that chelate calcium ions or act as ionophores interfere with the cellular environment necessary for tight junction formation, indirectly impacting Cldn34b1. Notably, these diverse mechanisms highlight the intricate web of molecular interactions that regulate Cldn34b1's function and emphasize the potential for nuanced modulation of tight junction dynamics through targeted chemical interventions.
In summary, Cldn34b1 stands at the intersection of crucial cellular processes, governing bicellular tight junction assembly and cell adhesion. The protein's involvement in these processes underscores its significance in maintaining the structural integrity of epithelial and endothelial barriers. The pursuit of inhibition strategies reveals a spectrum of chemical compounds capable of indirectly modulating Cldn34b1 through diverse pathways, ranging from calcium signaling and actin cytoskeleton dynamics to specific kinase activities. This intricate interplay of molecular mechanisms reflects the complexity of tight junction regulation, offering insights into potential avenues for further investigation and understanding of Cldn34b1's role in cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
A calcium channel blocker that indirectly inhibits Cldn34b1 by disrupting calcium signaling, essential for tight junction assembly. The inhibition of calcium influx influences the cellular environment, affecting the dynamics of tight junction formation and integrity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of Rho-associated kinase (ROCK) affecting the Rho/ROCK pathway. This compound disrupts actin cytoskeleton dynamics, indirectly influencing Cldn34b1 by impairing tight junction assembly. Inhibition of ROCK alters the signaling cascades contributing to tight junction integrity and function. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
A protein kinase C inhibitor that modulates signaling pathways impacting tight junction assembly. By inhibiting PKC, this compound indirectly influences Cldn34b1, disrupting junction organization and contributing to impaired tight junction dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
A myosin light chain kinase (MLCK) inhibitor affecting actin cytoskeleton dynamics. ML-7 disrupts the phosphorylation of myosin, indirectly influencing Cldn34b1 by impairing tight junction assembly. The compound alters the regulatory processes involved in maintaining tight junction integrity. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
A chelator for divalent cations like calcium, affecting the cellular environment crucial for tight junction assembly. EGTA disrupts the ion balance, indirectly influencing Cldn34b1 by impairing the interactions necessary for tight junction formation and integrity. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $102.00 $357.00 | 7 | |
An inhibitor of Rho-associated kinase (ROCK) affecting the Rho/ROCK pathway. This compound disrupts actin cytoskeleton dynamics, indirectly influencing Cldn34b1 by impairing tight junction assembly. Inhibition of ROCK alters the signaling cascades contributing to tight junction integrity and function. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
A selective inhibitor of protein kinase C (PKC) that modulates signaling pathways impacting tight junction assembly. By inhibiting PKC, this compound indirectly influences Cldn34b1, disrupting junction organization and contributing to impaired tight junction dynamics. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
An inhibitor of myosin II ATPase affecting actin cytoskeleton dynamics. Blebbistatin disrupts the phosphorylation of myosin, indirectly influencing Cldn34b1 by impairing tight junction assembly. The compound alters the regulatory processes involved in maintaining tight junction integrity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore affecting cellular calcium levels crucial for tight junction assembly. A23187 disrupts the ion balance, indirectly influencing Cldn34b1 by impairing the interactions necessary for tight junction formation and integrity. | ||||||
GSK 429286 | 864082-47-3 | sc-361200 sc-361200B sc-361200A | 1 mg 5 mg 10 mg | $39.00 $123.00 $230.00 | ||
A selective ROCK inhibitor impacting the Rho/ROCK pathway. This compound disrupts actin cytoskeleton dynamics, indirectly influencing Cldn34b1 by impairing tight junction assembly. Inhibition of ROCK alters the signaling cascades contributing to tight junction integrity and function. | ||||||