GSK 429286 (CAS 864082-47-3)

GSK 429286 is a compound potent and selective inhibition of the enzyme phosphoinositide 3-kinase (PI3K). By precisely binding to the ATP-binding pocket of the PI3K enzyme, GSK 429286 effectively blocks the enzymatic activity necessary for the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) into phosphatidylinositol 3,4,5-trisphosphate (PIP3). This action disrupts the PI3K/Akt signaling pathway, a conduit for regulating cellular functions such as growth, proliferation, and survival. The selectivity of GSK 429286 for PI3K over other kinases ensures minimal off-target effects, making it exemplary in molecular biology and biochemical for elucidating the complex roles of PI3K signaling. This inhibitor serves as a critical resource in various, facilitating detailed studies on the modulation of cellular processes and the investigation of PI3K′s involvement in diverse cellular states. Through these studies, GSK 429286 helps in advancing our understanding of cellular signaling networks, offering insights into the molecular dynamics that govern cell behavior under various physiological and pathophysiological conditions.