GSK 429286 CAS: 864082-47-3
MF: C21H16F4N4O2
MW: 432.37
A selective Rho-kinase inhibitor that reverses adrenalin-induced contraction.

GSK 429286 (CAS 864082-47-3)

GSK 429286 | CAS 864082-47-3 is rated 5.0 out of 5 by 1.
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Alternate Names: dihydropyridone indazole
Application: GSK 429286 is a selective Rho-kinase inhibitor that reverses adrenalin-induced contraction
CAS Number: 864082-47-3
Molecular Weight: 432.37
Molecular Formula: C21H16F4N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

GSK 429286 is a selective Rock (Rho-kinase) inhibitor(IC50 = 14 nM) that has been shown to reverse adrenalin-induced contraction of the rat aortic ring. GSK 429286 is an inhibitor of Rock-1.

Physical State :
Solid
Solubility :
Soluble in DMSO (87 mg/ml at 25° C), ethanol (25 mM), and water (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
290.40° C (Predicted)
Boiling Point :
~688.4° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
ROCK1: IC50 = 14 nM; ROCK2: IC50 = 63 nM; RSK : IC50 = 0.78 µM; p70S6K : IC50 = 1.94 µM
pK Values :
pKa: 12.1 (Predicted), pKb: 0.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11373846
MDL Number :
MFCD16618404
SMILES :
CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of GSK Various publications cite the use of GSK 429286 as a rho kinase inhibitor that has been shown to reverse adrenaline-mediated contraction. -SCBT Publication Review
Date published: 2015-01-27
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