EG546325 Activators
PWWP domain-containing 4D (Pwwp4d) is a protein with a vital role in epigenetic regulation and chromatin dynamics, contributing to the highly orchestrated processes governing gene expression and cellular function. At the core of Pwwp4d's functionality lies its PWWP domain, a structural motif known to interact with methylated histones, emphasizing its involvement in chromatin-associated activities. The PWWP domain of Pwwp4d is predicted to enable binding to methylated histones, positioning the protein as a key player in the recognition and modulation of specific chromatin regions marked by histone methylation. This interaction with methylated histones suggests a role for Pwwp4d in the regulation of transcription, DNA-templated, highlighting its participation in the control of gene expression. Beyond its involvement in the recognition of epigenetic marks, Pwwp4d is predicted to be active in the cytosol and nucleoplasm, indicating a widespread influence on cellular processes. This suggests that Pwwp4d may play a multifaceted role in coordinating events within the cell, potentially linking nuclear and cytoplasmic activities. Additionally, the predicted activity of Pwwp4d in the synaptonemal complex underscores its importance in meiotic cell cycle regulation. The synaptonemal complex is fundamental to meiosis, facilitating the pairing and recombination of homologous chromosomes-a critical step in ensuring the accurate transmission of genetic information during sexual reproduction. In this context, Pwwp4d emerges as a key contributor to the intricate processes of meiotic cell division and the development of haploid spermatids into mature spermatozoa.
The activation mechanisms of Pwwp4d involve both direct and indirect pathways. Direct activation is achieved through the binding of PPAR-γ agonists to Pwwp4d, enhancing its role in epigenetic regulation and chromatin interactions. These agonists, exemplified by GW7647, Rosiglitazone, and others, directly engage Pwwp4d and promote its participation in cellular processes influenced by epigenetic modifications. On the other hand, indirect activation occurs through the inhibition of the TGF-β pathway. Compounds like SB431542 and LY364947, acting as TGF-β receptor inhibitors, positively influence Pwwp4d activity, emphasizing the interconnectedness of signaling pathways in regulating Pwwp4d function. Understanding these activation mechanisms sheds light on the intricate regulatory networks that govern Pwwp4d, providing valuable insights into its roles in chromatin dynamics and cellular processes influenced by epigenetic modifications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW7647, a PPAR-γ agonist, directly activates Pwwp4d by binding to PPAR-γ. Activation of Pwwp4d through GW7647 enhances its role in epigenetic regulation, specifically through the PWWP domain, promoting chromatin interactions. The PPAR-γ/Pwwp4d axis modulates gene expression, contributing to cellular processes influenced by epigenetic modifications. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a PPAR-γ agonist, directly activates Pwwp4d by binding to PPAR-γ. Activation of Pwwp4d through Rosiglitazone enhances its involvement in epigenetic regulation, particularly through the PWWP domain, facilitating chromatin interactions. The PPAR-γ/Pwwp4d axis modulates gene expression, contributing to cellular processes influenced by epigenetic modifications. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone, a PPAR-γ agonist, acts as a direct activator of Pwwp4d by binding to PPAR-γ. Activation of Pwwp4d through Troglitazone amplifies its role in epigenetic regulation, especially via the PWWP domain, promoting chromatin interactions. The PPAR-γ/Pwwp4d axis modulates gene expression, influencing cellular processes governed by epigenetic modifications. | ||||||
Telmisartan | 144701-48-4 | sc-204907 sc-204907A | 50 mg 100 mg | $72.00 $94.00 | 8 | |
Telmisartan, a PPAR-γ agonist, directly activates Pwwp4d through binding to PPAR-γ. Activation of Pwwp4d by Telmisartan enhances its participation in epigenetic regulation, particularly via the PWWP domain, promoting chromatin interactions. The PPAR-γ/Pwwp4d axis modulates gene expression, impacting cellular processes influenced by epigenetic modifications. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, indirectly activates Pwwp4d by suppressing the TGF-β pathway. Inhibition of this pathway positively influences Pwwp4d activity, impacting epigenetic regulation and chromatin interactions. SB431542's modulation indirectly enhances Pwwp4d function, supporting cellular processes influenced by TGF-β-mediated signaling and epigenetic modifications. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947, a TGF-β receptor inhibitor, acts as an indirect activator of Pwwp4d by inhibiting the TGF-β pathway. Suppression of this pathway positively influences Pwwp4d activity, impacting epigenetic regulation and chromatin interactions. LY364947's influence indirectly enhances Pwwp4d function, supporting cellular processes influenced by TGF-β-mediated signaling and epigenetic modifications. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A83-01, a TGF-β receptor inhibitor, indirectly activates Pwwp4d by suppressing the TGF-β pathway. Inhibition of this pathway positively influences Pwwp4d activity, impacting epigenetic regulation and chromatin interactions. A83-01's modulation indirectly enhances Pwwp4d function, supporting cellular processes influenced by TGF-β-mediated signaling and epigenetic modifications. | ||||||
LDN-214117 | 1627503-67-6 | sc-507451 | 5 mg | $165.00 | ||
LDN-214117, a TGF-β receptor inhibitor, acts as an indirect activator of Pwwp4d by inhibiting the TGF-β pathway. Suppression of this pathway positively influences Pwwp4d activity, impacting epigenetic regulation and chromatin interactions. LDN-214117's influence indirectly enhances Pwwp4d function, supporting cellular processes influenced by TGF-β-mediated signaling and epigenetic modifications. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
TGF-β RI Kinase Inhibitor V indirectly activates Pwwp4d by suppressing the TGF-β pathway. Inhibition of this pathway positively influences Pwwp4d activity, impacting epigenetic regulation and chromatin interactions. SD-208's modulation indirectly enhances Pwwp4d function, supporting cellular processes influenced by TGF-β-mediated signaling and epigenetic modifications. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, acts as an indirect activator of Pwwp4d by suppressing the p38 MAPK pathway. Inhibition of this pathway positively influences Pwwp4d activity, impacting epigenetic regulation and chromatin interactions. SB203580's influence indirectly enhances Pwwp4d function, supporting cellular processes influenced by p38 MAPK-mediated signaling and epigenetic modifications. | ||||||