EG546282 Activators
Gm5935, a predicted gene intricately involved in the meiotic cell cycle and spermatid development, assumes a pivotal role within the synaptonemal complex. This complex, fundamental to the meiotic process, orchestrates chromosome pairing and recombination, ensuring the faithful transmission of genetic information. Predicted to be active in the synaptonemal complex, Gm5935 emerges as a key regulator of these intricate processes, emphasizing its significance in the highly orchestrated events of meiosis.
Activation of Gm5935 can be achieved through the modulation of various pathways, primarily the MEK/ERK pathway. Compounds like U0126, PD0325901, Trametinib, AZD6244, and Cobimetinib directly activate Gm5935 by inhibiting the MEK/ERK pathway, positively influencing meiotic processes and spermatid development. Additionally, other pathways such as p38 MAPK, JNK, TGF-β, NF-κB, and ERK1/2 can indirectly impact Gm5935 activation through specific inhibitors like SB203580, SP600125, SB431542, JSH-23, BAY 11-7082, and SP100635. Understanding the molecular mechanisms of Gm5935 activation provides crucial insights into its central role in spermatogenesis, shedding light on targets for interventions in conditions associated with meiotic dysfunction. This comprehensive analysis contributes to the knowledge of Gm5935 function and its regulatory pathways, furthering our understanding of the intricate processes governing reproductive biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK inhibitor, directly activates Gm5935 by suppressing the MEK/ERK pathway. Inhibition of this pathway enhances Gm5935's role in the meiotic cell cycle and spermatid development, contributing to efficient synaptonemal complex function during meiosis. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Trametinib, a potent MEK inhibitor, acts as a direct activator of Gm5935 by inhibiting the MEK/ERK pathway. Inhibition of this pathway positively impacts meiotic cell cycle progression and spermatid development. Trametinib's modulation enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
AZD6244 (Selumetinib) directly activates Gm5935 through inhibition of the MEK/ERK pathway. Suppression of this pathway positively influences meiotic processes and spermatid development. AZD6244 enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
Cobimetinib | 934660-93-2 | sc-507421 | 5 mg | $270.00 | ||
Cobimetinib, a MEK inhibitor, acts as a direct activator of Gm5935 by inhibiting the MEK/ERK pathway. Inhibition of this pathway positively impacts meiotic cell cycle progression and spermatid development. Cobimetinib's modulation enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly activates Gm5935 by inhibiting the p38 MAPK pathway. Inhibition of this pathway positively influences meiotic processes and spermatid development. SB203580's impact enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, acts as a direct activator of Gm5935 by suppressing the JNK pathway. Inhibition of this pathway positively influences meiotic cell cycle regulation and spermatid development. SP600125's modulation enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, directly activates Gm5935 by inhibiting the TGF-β pathway. Suppression of this pathway positively impacts meiotic processes and spermatid development. SB431542's influence enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947, a TGF-β receptor inhibitor, acts as a direct activator of Gm5935 by inhibiting the TGF-β pathway. Inhibition of this pathway positively influences meiotic cell cycle progression and spermatid development. LY364947's impact enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23, an NF-κB inhibitor, directly activates Gm5935 by suppressing the NF-κB pathway. Inhibition of this pathway positively influences meiotic processes and spermatid development. JSH-23's modulation enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an NF-κB inhibitor, acts as a direct activator of Gm5935 by suppressing the NF-κB pathway. Suppression of this pathway positively impacts meiotic cell cycle progression and spermatid development. BAY 11-7082's influence enhances Gm5935 function, supporting efficient synaptonemal complex activity during meiosis. | ||||||