Molecular structure of Cobimetinib, CAS Number: 934660-93-2
Cobimetinib (CAS 934660-93-2)
Alternate Names:
[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]-methanone
CAS Number:
934660-93-2
Molecular Weight:
531.3
Molecular Formula:
C21H21F3IN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Cobimetinib (CAS 934660-93-2) References
- Cost-effectiveness of encorafenib with binimetinib in unresectable or metastatic BRAF-mutant melanoma. | Trouiller, JB., et al. 2024. Eur J Health Econ. 25: 641-653. PMID: 37433888
- Real-world effectiveness of immune checkpoint inhibitors and BRAF/MEK inhibitors among veteran patients with cutaneous melanoma. | Kim, DY., et al. 2024. J Am Acad Dermatol. 90: 620-623. PMID: 37924953
- BRAF and MEK inhibitor combinations induce potent molecular and immunological effects in NRAS-mutant melanoma cells: Insights into mode of action and resistance mechanisms. | Dinter, L., et al. 2024. Int J Cancer. 154: 1057-1072. PMID: 38078628
- Primary results and characterization of patients with exceptional outcomes in a phase 1b study combining PARP and MEK inhibition, with or without anti-PD-L1, for BRCA wild-type, platinum-sensitive, recurrent ovarian cancer. | Mutch, D., et al. 2024. Cancer. 130: 1940-1951. PMID: 38288862
- Promising response to vemurafenib and cobimetinib treatment for BRAF V600E mutated craniopharyngioma: a case report and literature review. | Yu, N., et al. 2024. CNS Oncol. 13: CNS106. PMID: 38348829
- Venetoclax and Cobimetinib in Relapsed/Refractory AML: A Phase 1b Trial. | Konopleva, MY., et al. 2024. Clin Lymphoma Myeloma Leuk. 24: 364-374. PMID: 38378362
- Treatment of congenital Langerhans cell histiocytosis with cobimetinib. | Benjelloun, G., et al. 2024. Pediatr Dermatol. 41: 515-517. PMID: 38387093
- Treatment of Cerebral Histiocytosis With Low Dose of Cobimetinib: A Report of 2 Cases. | Schubert, C., et al. 2024. Neurol Neuroimmunol Neuroinflamm. 11: e200233. PMID: 38588479
- Rosmarinic acid activates the Ras/Raf/MEK/ERK signaling pathway to regulate CD8+ T cells and autophagy to clear Chlamydia trachomatis in reproductive tract-infected mice. | Yun, ZS., et al. 2024. Mol Immunol. 171: 105-114. PMID: 38820902
- EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of immune privilege. | Rutkowski, D., et al. 2024. Br J Dermatol.. PMID: 38857906
- MEK Inhibitor-Associated Ocular Hypertension. | Collet, DA., et al. 2024. Ocul Oncol Pathol. 10: 98-102. PMID: 38882021
- MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation. | Chen, Y., et al. 2024. PLoS Pathog. 20: e1011970. PMID: 38885264
- Advancements in the understanding and management of histiocytic neoplasms. | Koh, KN., et al. 2024. Blood Res. 59: 22. PMID: 38963520
Inhibitor of:
2700090O03Rik, 3100002L24Rik, 9330159F19Rik, AI987662, BAGE5, BC089597, Bcl-7b, BRAT1, C11orf49, C14orf93, C1orf227, C20orf160, Capicua, CCDC82, CT47B1, CT47C1, DCIR3, ERK 4, FAM149B1, FAM184A, FAM90A1, FLJ44815, Gm3696, Gm9766, gp100, GTF2IRD2, HACE1, HSTF4, KIAA1549, LOC100041261, LOC729103, LTH-A, MAGE-C3, MANBAL, MEAF6, mEH, MEK kinase-1, MEK kinase-2, MEK-1, MEK-4, MEK-5, MEK1, MEK2, Mel-CAM, Melan-A, Mos, NKAPL, Olfr209, Olr1029, Olr1061, Olr1065, Olr107, Olr113, Olr1155, Olr1156, Olr1204, Olr1206, Olr1231, Olr1334, Olr1385, Olr1404, Olr1564, Olr157, Olr165, Olr168, Olr1739, Olr175, Olr214, Olr223, Olr322, Olr357, Olr361, Olr375, Olr484, Olr530, Olr649, Olr655, Olr697, Olr726, Olr744, Olr773, Olr775, Olr788, Olr83, Olr920, Olr943, Olr962, Olr964, Pellino 2, Pet117, PHTF2, PRAMEF21, PTP-PEST, Raf-B, Ras-GRF2, RASA4, RASAL1, RASGEF1A, RASGEF1B, RASSF3, RIM-BP3B, Rsk-3, RSPRY1, SNFT, SPDYE2L, SPRED1, SPRED2, SS18L2, Ste5, Ste7, TDF, TFIIH p62, TNNI3K, TREM-2c, WDR65, and ZNF264.Activator of:
CD16-A, Cot, EG546272, EG546282, EGFL3, Melanoma, Melanoma Marker, Pdcd-1, PlGF, raf-A, and RAO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cobimetinib, 5 mg | sc-507421 | 5 mg | $270.00 |