EG546272 Activators
Gm5934, a predicted gene associated with meiotic cell cycle and spermatid development, plays a crucial role in regulating these processes, particularly within the synaptonemal complex. The predicted function involves participation in key cellular events contributing to successful spermatogenesis. The protein encoded by Gm5934, orthologous to human SYCP3, is implicated in spermatogenic failure 4.
Activation of Gm5934 can be achieved through the modulation of various pathways, predominantly the MEK/ERK pathway. Compounds like U0126, PD0325901, Trametinib, AZD6244, and Cobimetinib directly activate Gm5934 by inhibiting the MEK/ERK pathway, positively influencing meiotic cell cycle progression and spermatid development. Additionally, other pathways such as p38 MAPK, JNK, TGF-β, NF-κB, and ERK1/2 can indirectly impact Gm5934 activation through specific inhibitors like SB203580, SB431542, JSH-23, BAY 11-7082, and SP100635. Understanding the molecular mechanisms of Gm5934 activation provides insights into its vital role in spermatogenesis, creating the opportunity for new discoveries in conditions associated with spermatogenic failure. This comprehensive analysis contributes to the knowledge of Gm5934 function and its regulatory pathways in the context of reproductive biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK inhibitor, acts as a direct activator of Gm5934 by suppressing the MEK/ERK pathway. Inhibition of this pathway positively influences meiotic cell cycle progression and spermatid development. U0126's impact on the pathway enhances Gm5934 activity, supporting synaptonemal complex function during spermatogenesis. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Trametinib, a potent MEK inhibitor, acts as a direct activator of Gm5934 by inhibiting the MEK/ERK pathway. Suppression of this pathway positively impacts meiotic cell cycle regulation and spermatid development. Trametinib's influence on the pathway enhances Gm5934 function, supporting synaptonemal complex activity in spermatogenesis. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
AZD6244 (Selumetinib) directly activates Gm5934 through inhibition of the MEK/ERK pathway. Suppression of this pathway positively influences meiotic cell cycle processes and spermatid development. AZD6244 enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
Cobimetinib | 934660-93-2 | sc-507421 | 5 mg | $270.00 | ||
Cobimetinib, a MEK inhibitor, acts as a direct activator of Gm5934 by inhibiting the MEK/ERK pathway. Inhibition of this pathway positively impacts meiotic cell cycle progression and spermatid development. Cobimetinib's modulation of the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly activates Gm5934 by inhibiting the p38 MAPK pathway. Inhibition of this pathway positively influences meiotic cell cycle processes and spermatid development. SB203580's impact on the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, acts as a direct activator of Gm5934 by suppressing the JNK pathway. Inhibition of this pathway positively influences meiotic cell cycle regulation and spermatid development. SP600125's modulation of the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, directly activates Gm5934 by inhibiting the TGF-β pathway. Suppression of this pathway positively impacts meiotic cell cycle progression and spermatid development. SB431542's influence on the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947, a TGF-β receptor inhibitor, acts as a direct activator of Gm5934 by inhibiting the TGF-β pathway. Inhibition of this pathway positively influences meiotic cell cycle processes and spermatid development. LY364947's impact on the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23, an NF-κB inhibitor, directly activates Gm5934 by suppressing the NF-κB pathway. Inhibition of this pathway positively influences meiotic cell cycle regulation and spermatid development. JSH-23's modulation of the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an NF-κB inhibitor, acts as a direct activator of Gm5934 by suppressing the NF-κB pathway. Suppression of this pathway positively impacts meiotic cell cycle progression and spermatid development. BAY 11-7082's influence on the pathway enhances Gm5934 function, supporting synaptonemal complex activity during spermatogenesis. | ||||||