EG546143 Activators
Pierce2, identified as the piercer of microtubule wall 2, plays a pivotal role in maintaining microtubule integrity and stability. Primarily expressed in the embryo and node, Pierce2 is orthologous to the human C15orf65 gene, emphasizing its evolutionary significance. The gene's predicted function involves fortifying microtubules, essential structures for cellular architecture and intracellular transport. Activation of Pierce2 is intricately linked to microtubule dynamics. Compounds such as paclitaxel and epothilones directly up-regulate Pierce2 by stabilizing microtubules, reinforcing their structure. On the other hand, microtubule-depolymerizing agents like nocodazole and vincristine indirectly activate Pierce2 by triggering compensatory responses that enhance its expression and activity to counteract microtubule destabilization. These chemicals orchestrate a delicate balance, either reinforcing or destabilizing microtubules, leading to Pierce2 activation through distinct yet interconnected pathways.
The general mechanism of Pierce2 activation involves a dynamic interplay between chemicals and microtubules. Direct activators enhance microtubule stability, directly up-regulating Pierce2, while indirect activators induce compensatory responses to maintain microtubule integrity. This dual modality allows Pierce2 to respond adaptively to microtubule dynamics, showcasing its crucial role in cellular architecture. This comprehensive understanding sheds light on the nuanced ways in which Pierce2 orchestrates microtubule stability, underlining its significance in cellular processes.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol up-regulates Pierce2 by stabilizing microtubules. Acting as a microtubule-stabilizing agent, it enhances the polymerization and stability of microtubules, leading to increased Pierce2 activity in promoting microtubule wall integrity. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B directly activates Pierce2 by promoting microtubule stability. It mimics the action of paclitaxel and enhances microtubule polymerization, reinforcing the microtubule wall through direct interaction with Pierce2, thereby up-regulating its activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole indirectly activates Pierce2 by destabilizing microtubules. As a microtubule-depolymerizing agent, it disrupts microtubule structure, triggering a compensatory response that up-regulates Pierce2 to restore microtubule wall integrity through increased expression and activity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine up-regulates Pierce2 by destabilizing microtubules. It disrupts microtubule dynamics, leading to a compensatory up-regulation of Pierce2 to maintain microtubule wall integrity. The destabilizing effect indirectly activates Pierce2 through the cellular response to microtubule damage. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine indirectly activates Pierce2 by disrupting microtubules. Its microtubule-destabilizing action triggers an up-regulation of Pierce2 expression and activity to restore microtubule integrity. This indirect activation is a cellular response to microtubule damage caused by colchicine. | ||||||
Epothilone D | 189453-10-9 | sc-207630 sc-207630A sc-207630B sc-207630C | 1 mg 25 mg 100 mg 250 mg | $406.00 $988.00 $3121.00 $5202.00 | ||
Epothilone D directly activates Pierce2 by enhancing microtubule stability. Similar to epothilone B, it promotes microtubule polymerization, reinforcing the microtubule wall and directly up-regulating Pierce2 activity in maintaining microtubule integrity. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin indirectly activates Pierce2 by disrupting microtubules. Its microtubule-destabilizing effect leads to an up-regulation of Pierce2 expression and activity as a compensatory response, restoring microtubule integrity in the presence of griseofulvin-induced microtubule damage. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $29.00 $81.00 $260.00 $791.00 $1977.00 | ||
Vinorelbine up-regulates Pierce2 by destabilizing microtubules. Similar to vincristine, its microtubule-depolymerizing action triggers an up-regulation of Pierce2, maintaining microtubule wall integrity in response to the destabilizing effect induced by vinorelbine. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin indirectly activates Pierce2 by disrupting microtubules. Its microtubule-destabilizing action triggers an up-regulation of Pierce2 expression and activity, compensating for the microtubule damage caused by podophyllotoxin and ensuring the maintenance of microtubule wall integrity. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combrestatin A4 directly activates Pierce2 by promoting microtubule stability. Its microtubule-stabilizing effect enhances polymerization, reinforcing the microtubule wall and directly up-regulating Pierce2 activity in maintaining microtubule integrity. | ||||||