Molecular structure of Epothilone D, CAS Number: 189453-10-9�
Epothilone D (CAS 189453-10-9)
Alternate Names:
desoxyepothilone B
Application:
Epothilone D is an intermediary obtained in the synthesis of members of the epothilone family
CAS Number:
189453-10-9
Molecular Weight:
491.68
Molecular Formula:
C27H41NO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Epothilone D (synthetic) is an intermediary obtained in the synthesis of members of the epothilone family, natural polyketide compounds that inhibit cancer cells via a mechanism similar to paclitaxel. It has also been found to be effective against paclitaxel-resistant tumors.
Epothilone D (CAS 189453-10-9) References
- New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | Hardt, IH., et al. 2001. J Nat Prod. 64: 847-56. PMID: 11473410
- Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F. | Gerth, K., et al. 2002. J Antibiot (Tokyo). 55: 41-5. PMID: 11918064
- Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. | Killinger, BA. and Moszczynska, A. 2016. J Neurochem. 136: 510-25. PMID: 26465779
- Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates. | Valdinocci, D., et al. 2018. Mol Cell Neurosci. 89: 80-94. PMID: 29673913
- Synthesis and Activity of Epothilone D. | Cheng, H. and Huang, G. 2018. Curr Drug Targets. 19: 1866-1870. PMID: 30073925
- Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro. | Clark, JA., et al. 2020. Sci Rep. 10: 918. PMID: 31969604
- Upregulation of Apol8 by Epothilone D facilitates the neuronal relay of transplanted NSCs in spinal cord injury. | Xue, W., et al. 2021. Stem Cell Res Ther. 12: 300. PMID: 34039405
- Epothilone D Modulates Autism-like Behaviors in the BTBR Mouse Model of Autism Spectrum Disorder. | Zhao, M., et al. 2022. Neuroscience. 490: 171-181. PMID: 35227832
- Rehabilitation enhances epothilone-induced locomotor recovery after spinal cord injury. | Griffin, JM., et al. 2023. Brain Commun. 5: fcad005. PMID: 36744011
- Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. | Bollag, DM., et al. 1995. Cancer Res. 55: 2325-33. PMID: 7757983
Inhibitor of:
Tau.Activator of:
EG546143.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Epothilone D, 1 mg | sc-207630 | 1 mg | $406.00 | |||
Epothilone D, 25 mg | sc-207630A | 25 mg | $988.00 | |||
Epothilone D, 100 mg | sc-207630B | 100 mg | $3121.00 | |||
Epothilone D, 250 mg | sc-207630C | 250 mg | $5202.00 |