EG545948 Activators
Scgb1b20, a member of the secretoglobin family, is predicted to enable steroid binding activity and is localized in the extracellular region. This gene plays a vital role in mediating responses to steroid signaling. Activation of Scgb1b20 involves intricate modulation by various chemical regulators, impacting its transcription and steroid binding activity. Chemical agonists such as GW3965, Retinoic Acid, and Spironolactone stimulate Scgb1b20 by activating LXR, RAR, and MR, respectively. These events influence Scgb1b20 transcription, enhancing its expression and steroid binding in the extracellular region. Similarly, modulators like 22(R)-Hydroxycholesterol and Pregnenolone affect oxysterol-dependent pathways and Pregnenolone receptor, indirectly promoting Scgb1b20 steroid binding activity.
Dexamethasone, Calcitriol, Testosterone, and 17β-Estradiol act as agonists for GR, VDR, AR, and ER, respectively, stimulating Scgb1b20 expression and steroid binding. GW1929 activates PPARγ, contributing to Scgb1b20 transcription and steroid binding. Additionally, DHEA and 5α-Dihydrotestosterone modulate Scgb1b20 activity by acting as agonists for their respective receptors. In summary, the activation of Scgb1b20 involves a complex interplay of chemical regulators, finely tuning its response to steroid signaling. This comprehensive understanding sheds light on the mechanisms by which Scgb1b20 contributes to cellular functions, emphasizing its role in steroid binding and extracellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $137.00 $474.00 $3060.00 | ||
Liver X receptor (LXR) agonist enhancing Scgb1b20 expression. GW3965 activates LXR, promoting Scgb1b20 transcription and steroid binding activity in the extracellular region. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid receptor (RAR) agonist modulating Scgb1b20 activity. Retinoic Acid activates RAR, influencing Scgb1b20 function and steroid binding in the extracellular region. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Mineralocorticoid receptor (MR) agonist stimulating Scgb1b20 expression. Spironolactone activates MR, promoting Scgb1b20 transcription and steroid binding in the extracellular region. | ||||||
22(R)-hydroxycholesterol | 17954-98-2 | sc-205106 sc-205106A sc-205106B | 1 mg 5 mg 10 mg | $108.00 $350.00 $600.00 | 1 | |
Oxysterol influencing Scgb1b20 activity. 22(R)-Hydroxycholesterol modulates oxysterol-dependent pathways, indirectly promoting Scgb1b20 steroid binding activity in the extracellular region. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $85.00 $145.00 $340.00 $1100.00 | ||
Pregnenolone receptor agonist enhancing Scgb1b20 expression. Pregnenolone activates its receptor, influencing Scgb1b20 transcription and promoting steroid binding in the extracellular region. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoid receptor (GR) agonist stimulating Scgb1b20 expression. Dexamethasone activates GR, promoting Scgb1b20 transcription and steroid binding in the extracellular region. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Vitamin D receptor (VDR) agonist modulating Scgb1b20 activity. Calcitriol activates VDR, influencing Scgb1b20 function and steroid binding in the extracellular region. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estrogen receptor (ER) agonist stimulating Scgb1b20 expression. 17β-Estradiol activates ER, promoting Scgb1b20 transcription and steroid binding in the extracellular region. | ||||||
GW 1929 | 196808-24-9 | sc-202640 | 1 mg | $89.00 | ||
Peroxisome proliferator-activated receptor gamma (PPARγ) agonist enhancing Scgb1b20 expression. GW1929 activates PPARγ, promoting Scgb1b20 transcription and steroid binding in the extracellular region. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
DHEA receptor agonist modulating Scgb1b20 activity. DHEA activates its receptor, influencing Scgb1b20 function and steroid binding in the extracellular region. | ||||||