EG436523 Activators
Prss1l, encoding for serine protease 1 (trypsin 1) like protein, exhibits a predicted function involving serine-type endopeptidase activity and participation in proteolysis. The gene is predominantly located in the collagen-containing extracellular matrix, aligning with its potential role in extracellular processes. Activation of Prss1l involves a complex interplay of various chemical regulators, each influencing specific pathways and mechanisms.
The gene's up-regulation can be achieved through histone modifications, as exemplified by Trichostatin A and Sodium Butyrate, which act as histone deacetylase inhibitors, modifying chromatin structure and enhancing the accessibility of Prss1l promoter regions. Forskolin, through cAMP elevation, triggers PKA signaling, positively impacting Prss1l expression via cAMP-responsive elements in its promoter. Retinoic Acid, a ligand for retinoic acid receptors, directly influences Prss1l transcription by binding to specific response elements in its promoter. The calcium ionophore A23187 activates Prss1l through calcium-dependent pathways, leading to phosphorylation events and increased promoter accessibility. These chemicals collectively modulate Prss1l expression through intricate signaling cascades and epigenetic modifications, providing insights into potential strategies for targeted activation in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor impacting chromatin structure, leading to increased accessibility of the Prss1l promoter. Activation is achieved by enhancing the transcriptional machinery's access to the gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid receptor agonist influencing gene transcription. Prss1l is a target of retinoic acid, and activation involves binding of the ligand-receptor complex to specific response elements in its promoter. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor modifying chromatin structure and promoting Prss1l expression. Indirect activation occurs via epigenetic changes in the gene promoter, facilitating enhanced transcription. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Protein kinase C activator initiating signaling cascades. Prss1l activation is achieved through downstream kinase-mediated phosphorylation events, enhancing the accessibility of the gene promoter. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Solvent with potential epigenetic effects, influencing Prss1l expression indirectly. DMSO can modulate chromatin structure, affecting transcription factor binding and thereby impacting the gene's activation. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Short-chain fatty acid influencing histone acetylation and chromatin structure. Prss1l activation is achieved through epigenetic modifications, facilitating an open chromatin state and increased gene expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore activating signaling cascades. Prss1l activation involves calcium-dependent pathways, leading to phosphorylation events and enhanced accessibility of the gene promoter for transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor impacting DNA methylation patterns. Prss1l activation is achieved by demethylation of its promoter region, allowing for increased binding of transcriptional machinery and gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Histone deacetylase inhibitor altering chromatin conformation and promoting Prss1l expression. Activation is mediated through epigenetic modifications facilitating increased accessibility of the gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Sirtuin activator influencing histone deacetylation. Prss1l activation is mediated through sirtuin-dependent epigenetic modifications, leading to an open chromatin state and enhanced accessibility of the gene promoter. | ||||||