EG331493 Activators
Gm5127, a predicted gene, exhibits a distinct functional profile characterized by its involvement in G protein-coupled receptor (GPCR) activity and positive regulation of critical cellular processes, including Rho protein signal transduction and cytosolic calcium ion concentration modulation through the phospholipase C-activating GPCR signaling pathway. As an integral component of the plasma membrane, Gm5127 plays a pivotal role in orchestrating cellular responses to extracellular signals. The activation of Gm5127 involves a complex interplay of signaling pathways and cellular processes, and understanding these mechanisms unveils its significance in cellular communication and regulation.
The intricate activation of Gm5127 can be achieved through various chemicals that modulate key components of GPCR signaling cascades. Forskolin, for instance, activates Gm5127 by stimulating adenylate cyclase, leading to increased cAMP levels and subsequent GPCR activity. Isoproterenol and Carbachol engage β-adrenergic and muscarinic receptors, respectively, initiating downstream signaling events that positively regulate Gm5127. PMA activates protein kinase C, influencing Rho protein signal transduction and promoting GPCR activity. Thapsigargin indirectly up-regulates Gm5127 by depleting ER calcium stores, enhancing phospholipase C signaling. These chemicals collectively contribute to the dynamic regulation of Gm5127, unveiling its role as a key player in the intricate network of GPCR-mediated cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates Gm5127 by binding to β-adrenergic receptors, triggering adenylate cyclase and elevating cAMP levels, promoting receptor activity. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol activates Gm5127 by binding to muscarinic receptors, initiating phospholipase C signaling and raising cytosolic calcium levels, promoting receptor activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA stimulates Gm5127 by activating protein kinase C, influencing Rho protein signal transduction pathways and promoting G protein-coupled receptor activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly up-regulates Gm5127 by depleting ER calcium stores, activating store-operated calcium entry and enhancing phospholipase C signaling. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates Gm5127 by binding to G protein-coupled receptors, initiating phospholipase C signaling and promoting positive regulation of cytosolic calcium levels. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 activates Gm5127 by enhancing L-type calcium channel activity, promoting influx of extracellular calcium and positive regulation of cytosolic calcium levels. | ||||||
Ginsenoside Rg1 | 22427-39-0 | sc-205708 sc-205708A | 5 mg 10 mg | $265.00 $486.00 | ||
Ginsenoside Rg1 stimulates Gm5127 by influencing Rho protein signal transduction pathways, promoting G protein-coupled receptor activity. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid up-regulates Gm5127 by affecting membrane composition, influencing the integrity of integral components of the plasma membrane, and promoting receptor activity. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine activates Gm5127 by binding to histamine receptors, initiating phospholipase C signaling and elevating cytosolic calcium levels, promoting G protein-coupled receptor activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate stimulates Gm5127 through S1P receptors, initiating signaling cascades that positively regulate Rho protein activity and enhance G protein-coupled receptor function. | ||||||