EG240327 Activators
Iigp1c, an interferon-inducible GTPase 1C, is a pivotal player in cellular responses to interferon-beta. This gene is predicted to enable GTPase activity, indicating its involvement in critical intracellular processes. Acting upstream of or within the cellular response to interferon-beta, Iigp1c operates within the endoplasmic reticulum membrane, highlighting its significance in cellular homeostasis. The primary function of Iigp1c is intricately tied to its role as a responder to interferon-beta, suggesting its involvement in antiviral and immune response pathways. The activation of Iigp1c involves a complex interplay of signaling pathways and cellular processes. Various chemicals, acting as indirect activators, modulate specific biochemical pathways to influence the expression and activity of Iigp1c. These pathways include SIRT1, NF-κB, PI3K/Akt, NRF2, Keap1-Nrf2, AMPK, MAPK/ERK, JAK/STAT, PPARγ, TLR4, and HSP90. Through these diverse mechanisms, Iigp1c undergoes up-regulation, stimulation, and enhancement, ultimately amplifying its GTPase activity at the endoplasmic reticulum membrane. The intricate network of pathways indicates the adaptability of Iigp1c in responding to various cellular cues, emphasizing its versatility in influencing cellular responses to interferon-beta.
In conclusion, Iigp1c stands as a key component in the cellular machinery responding to interferon-beta, contributing to the intricate network of antiviral and immune responses. Its activation is finely regulated by a spectrum of chemicals, each influencing specific pathways that converge to modulate Iigp1c expression and function. The complexity of these interactions underscores the importance of Iigp1c in maintaining cellular integrity and highlights its potential role in shaping cellular responses to external stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, activates Iigp1c indirectly by modulating the SIRT1 pathway. By enhancing SIRT1 deacetylase activity, it triggers cellular responses to interferon-beta, influencing the endoplasmic reticulum membrane's functionality and up-regulating Iigp1c. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin acts as an indirect activator of Iigp1c by inhibiting the NF-κB pathway. Its interference with NF-κB signaling leads to up-regulation and stimulation of Iigp1c in response to interferon-beta, positioning it at the endoplasmic reticulum membrane. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin serves as an indirect activator, influencing Iigp1c via the PI3K/Akt pathway. By enhancing Akt phosphorylation, it amplifies cellular responses to interferon-beta and promotes the GTPase activity of Iigp1c in the endoplasmic reticulum membrane. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, through NRF2 activation, indirectly up-regulates Iigp1c. By modulating the Keap1-NRF2 pathway, it triggers cellular responses to interferon-beta, enhancing Iigp1c GTPase activity at the endoplasmic reticulum membrane. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $60.00 $165.00 | 6 | |
Carnosic Acid acts as an indirect activator by promoting Nrf2 activity. By influencing the Keap1-Nrf2 pathway, it triggers cellular responses to interferon-beta, stimulating Iigp1c GTPase activity at the endoplasmic reticulum membrane. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate serves as an indirect activator by modulating the AMPK pathway. By enhancing AMPK phosphorylation, it triggers cellular responses to interferon-beta, influencing the endoplasmic reticulum membrane and up-regulating Iigp1c GTPase activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an indirect activator, influences Iigp1c through the MAPK/ERK pathway. By enhancing ERK phosphorylation, it triggers cellular responses to interferon-beta, promoting Iigp1c GTPase activity at the endoplasmic reticulum membrane. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin serves as an indirect activator, affecting Iigp1c through the JAK/STAT pathway. By modulating STAT3 phosphorylation, it triggers cellular responses to interferon-beta, influencing the endoplasmic reticulum membrane and up-regulating Iigp1c GTPase activity. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid acts as an indirect activator by enhancing PPARγ activity. Through the PPARγ pathway, it triggers cellular responses to interferon-beta, influencing the endoplasmic reticulum membrane and promoting Iigp1c GTPase activity. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
Oleanolic Acid serves as an indirect activator, influencing Iigp1c through the PI3K/Akt pathway. By enhancing Akt phosphorylation, it triggers cellular responses to interferon-beta, promoting Iigp1c GTPase activity at the endoplasmic reticulum membrane. | ||||||