Date published: 2026-2-14

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EF-CAB2 Inhibitors

EF-CAB2 Inhibitors encompass a collection of chemical compounds that, through various mechanisms, achieve the decreased activity of EF-CAB2 by influencing calcium signaling and homeostasis. Nifedipine, Verapamil, Diltiazem, Bepridil, Mibefradil, and Nimodipine function as calcium channel blockers; they limit the influx of calcium ions across the cell membrane, which is crucial for the calcium-dependent regulatory functions of EF-CAB2. By reducing the intracellular calcium concentration, these inhibitors diminish the ability of EF-CAB2 to bind calcium, which is necessary for its activity. Amlodipine operates similarly by impeding the flow of calcium ions into cells, further contributing to the indirect inhibition of EF-CAB2's calcium-reliant functions. SK&F 96365 and 2-APB reduce receptor-mediated and store-operated calcium entry, respectively, thereby indirectly reducing EF-CAB2 activity by limiting intracellular calcium signaling pathways. In addition to these, Thapsigargin and Ryanodine disrupt calcium storage and release from intracellular stores such as the endoplasmic reticulum, leading to a depletion of calcium ions necessary for EF-CAB2's function. Thapsigargin inhibits the SERCA pump, thereby preventing the reuptake of calcium into the ER, while Ryanodine alters the ryanodine receptor-operated channels, both culminating in the reduction of EF-CAB2 activity due to decreased calcium availability. BAPTA/AM serves as a calcium chelator within cells, sequestering calcium and thus indirectly inhibiting the functional activity of EF-CAB2 by reducing the free calcium ion concentration that it requires for activity. Collectively, these EF-CAB2 inhibitors exert their effects by diminishing the cellular calcium concentration or interfering with calcium signaling.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$59.00
$173.00
15
(1)

Nifedipine, a calcium channel blocker, inhibits L-type calcium channels. By reducing calcium influx, it indirectly decreases the activity of EF-CAB2, which is calcium-binding and whose function is calcium-dependent.

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Verapamil is another calcium channel blocker that targets L-type calcium channels. It diminishes intracellular calcium, thereby indirectly inhibiting the calcium-dependent functions of EF-CAB2.

Diltiazem

42399-41-7sc-204726
sc-204726A
1 g
5 g
$209.00
$464.00
4
(1)

Diltiazem, as a calcium channel antagonist, limits calcium entry through voltage-gated calcium channels, reducing the calcium-dependent regulatory functions of EF-CAB2.

Bepridil

64706-54-3sc-507400
100 mg
$1620.00
(0)

Bepridil is a calcium channel blocker with a broad range of action, which includes the inhibition of voltage-gated calcium channels, leading to a decrease in EF-CAB2 activity due to reduced calcium levels.

Mibefradil dihydrochloride

116666-63-8sc-204083
sc-204083A
10 mg
50 mg
$213.00
$865.00
4
(1)

Mibefradil selectively inhibits T-type calcium channels, which indirectly leads to diminished EF-CAB2 activity by lowering the availability of calcium ions necessary for its function.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$28.00
$53.00
37
(1)

2-APB is an IP3 receptor antagonist and also modulates store-operated calcium entry, thus indirectly decreasing the activity of EF-CAB2 by affecting calcium signaling pathways.

SK&F 96365

130495-35-1sc-201475
sc-201475B
sc-201475A
sc-201475C
5 mg
10 mg
25 mg
50 mg
$103.00
$158.00
$397.00
$656.00
2
(1)

SK&F 96365 inhibits receptor-mediated calcium entry, which would reduce calcium-dependent signaling, consequently diminishing the activity of EF-CAB2.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin is a SERCA pump inhibitor that leads to depletion of ER calcium stores. Reduced calcium availability indirectly inhibits the functional activity of EF-CAB2.

BAPTA/AM

126150-97-8sc-202488
sc-202488A
25 mg
100 mg
$138.00
$458.00
61
(2)

BAPTA/AM is a cell-permeable calcium chelator that sequesters intracellular calcium, thus indirectly reducing the regulatory functions of EF-CAB2 that depend on calcium binding.

Ryanodine

15662-33-6sc-201523
sc-201523A
1 mg
5 mg
$223.00
$799.00
19
(2)

Ryanodine locks ryanodine receptor-operated calcium channels in a subconductance state, thereby diminishing intracellular calcium levels and indirectly inhibiting the activity of EF-CAB2.