ECRG4 Activators
ECRG4 Activators belong to a distinctive chemical class that has garnered attention for its role in modulating cellular processes. At the molecular level, these activators interact with the extracellular signal-regulated kinase 5 (ERK5) pathway, a crucial signaling cascade implicated in various cellular functions, including proliferation, differentiation, and survival. The term ECRG4 refers to the esophageal cancer-related gene 4, a gene encoding a protein that has been associated with the regulation of ERK5 activity. ECRG4 Activators act as small molecules capable of enhancing the activation of the ERK5 pathway, thus influencing downstream cellular responses.
Structurally, ECRG4 Activators often possess specific motifs that enable their binding to key components of the ERK5 pathway. Through this interaction, these compounds facilitate the phosphorylation and activation of ERK5, triggering a cascade of events within the cell. The activation of ERK5, in turn, leads to the modulation of transcription factors and the expression of genes involved in cellular functions. The intricate interplay between ECRG4 Activators and the ERK5 pathway highlights the potential of these compounds as tools for elucidating the complex signaling networks governing cellular behavior. Research into the mechanisms and downstream effects of ECRG4 Activators continues to shed light on their role in cellular physiology, contributing to our broader understanding of signal transduction pathways and their implications in various biological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate target proteins leading to changes in their activity. ECRG4 is a protein that can be influenced by PKA-mediated phosphorylation, thereby enhancing its functional activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cAMP analog that resists degradation by phosphodiesterases. This compound maintains elevated intracellular cAMP levels, thereby continually activating PKA. This sustained PKA activity can lead to the phosphorylation and subsequent activation of ECRG4. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, which are enzymes responsible for the breakdown of cAMP. By preventing cAMP degradation, IBMX indirectly increases PKA activity, which can enhance the phosphorylation state and activity of ECRG4. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, which leads to an accumulation of cAMP in cells. The resulting PKA activation due to increased cAMP levels can contribute to the functional enhancement of ECRG4 through phosphorylation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic beta-adrenergic agonist that stimulates adenylyl cyclase activity and increases intracellular cAMP levels. By activating PKA, isoproterenol can enhance the phosphorylation and activity of ECRG4. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, also known as adrenaline, binds to and activates beta-adrenergic receptors, which in turn stimulates adenylyl cyclase and increases cAMP levels. The PKA pathway activation can lead to an increase in ECRG4 activity through phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with G-protein coupled receptors that can engage the cAMP/PKA signaling pathway. Through this pathway, PGE2 can enhance the activation of ECRG4 indirectly. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can activate H2 receptors which are positively linked to adenylyl cyclase, leading to an increase in intracellular cAMP and activation of PKA. This can enhance the functional activity of ECRG4 through signaling cascades involving PKA. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits phosphodiesterase III (PDE3), leading to an increase in cAMP levels within cells. The resulting PKA activation can enhance the activation of ECRG4 through phosphorylation. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a selective beta2-adrenergic receptor agonist that induces adenylyl cyclase activity, which increases cAMP levels. This elevation of cAMP leads to PKA activation, which can enhance the functional activity of ECRG4. | ||||||