EAAT Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Evans Blue | 314-13-6 | sc-203736B sc-203736 sc-203736A | 1 g 10 g 50 g | $47.00 $69.00 $265.00 | 15 | |
Evans Blue is a sulfonated dye that exhibits unique interactions with plasma proteins, particularly albumin, leading to its use as a tracer in vascular studies. Its affinity for binding to serum proteins alters its distribution and retention in tissues, influencing its kinetics in biological systems. The dye's distinct spectral properties allow for precise quantification in various assays, while its ability to permeate cell membranes under specific conditions highlights its role in studying membrane dynamics and permeability. | ||||||
Chicago Sky Blue 6B | 2610-05-1 | sc-361146 sc-361146A sc-361146B | 25 g 100 g 250 g | $117.00 $326.00 $627.00 | ||
Chicago Sky Blue 6B is a synthetic dye characterized by its strong affinity for anionic sites, facilitating unique interactions with various biomolecules. Its distinct chromophoric structure allows for selective absorption in the visible spectrum, making it useful in colorimetric assays. The dye's stability in aqueous solutions and its ability to form complexes with metal ions enhance its reactivity, influencing its behavior in different chemical environments and pathways. | ||||||
7-Chlorokynurenic acid | 18000-24-3 | sc-358717 sc-358717A | 10 mg 50 mg | $83.00 $349.00 | ||
7-Chlorokynurenic acid is a potent antagonist of excitatory amino acid transporters (EAATs), exhibiting unique binding dynamics that disrupt glutamate uptake. Its structural features enable specific interactions with the transporter's binding sites, altering reaction kinetics and influencing neurotransmitter cycling. This compound's ability to modulate synaptic activity highlights its role in neurochemical pathways, providing insights into excitatory signaling mechanisms. | ||||||
(±)-HIP-A | 227619-64-9 | sc-203598 | 10 mg | $131.00 | ||
(±)-HIP-A functions as an effective modulator of excitatory amino acid transporters (EAATs), characterized by its ability to selectively inhibit glutamate transport. Its unique molecular structure facilitates specific interactions with the transporter's active sites, leading to altered conformational states. This modulation impacts the kinetics of glutamate reuptake, thereby influencing synaptic transmission and contributing to the regulation of excitatory neurotransmission in neural circuits. | ||||||
1-Aminocyclobutane-trans-1,3-dicarboxylic acid | 73550-55-7 | sc-361072 sc-361072A | 10 mg 50 mg | $139.00 $585.00 | ||
1-Aminocyclobutane-trans-1,3-dicarboxylic acid exhibits distinctive properties as an excitatory amino acid transporter (EAAT) modulator. Its cyclic structure allows for unique steric interactions with the transport protein, enhancing binding affinity and altering transport dynamics. This compound influences the conformational flexibility of the transporter, thereby affecting the rate of substrate translocation and the overall efficiency of glutamate clearance from synaptic clefts. | ||||||
7-Chlorokynurenic acid sodium salt | 1263094-00-3 | sc-291578 sc-291578A | 10 mg 50 mg | $95.00 $399.00 | ||
7-Chlorokynurenic acid sodium salt acts as a potent modulator of excitatory amino acid transporters (EAATs) through its unique halogenated structure, which introduces specific electronic effects that influence protein interactions. The presence of the chlorine atom enhances hydrophobic interactions, potentially stabilizing the transporter in specific conformations. This compound may also alter the kinetics of substrate binding and release, impacting the overall transport mechanism and glutamate homeostasis. | ||||||