Molecular structure of 7-Chlorokynurenic acid sodium salt, CAS Number: 1263094-00-3
7-Chlorokynurenic acid sodium salt (CAS 1263094-00-3)
Alternate Names:
7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Application:
7-Chlorokynurenic acid sodium salt is an NMDA receptor antagonist and inhibitor of EAAT
CAS Number:
1263094-00-3
Purity:
≥98%
Molecular Weight:
245.60
Molecular Formula:
C10H5CINNaO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
7-Chlorokynurenic acid sodium salt is an NMDA receptor antagonist acting at the glycine site. 7-Chlorokynurenic acid sodium salt acts as a potent competitive inhibitor of EAAT (L-glutamate transporter) into synaptic vesicles.
7-Chlorokynurenic acid sodium salt (CAS 1263094-00-3) References
- Hebbian Spike-Timing Dependent Plasticity at the Cerebellar Input Stage. | Sgritta, M., et al. 2017. J Neurosci. 37: 2809-2823. PMID: 28188217
- 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. | Kemp, JA., et al. 1988. Proc Natl Acad Sci U S A. 85: 6547-50. PMID: 2842779
- Subsaturation of the N-methyl-D-aspartate receptor glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons. | Destreel, G., et al. 2019. Eur J Neurosci. 50: 3454-3471. PMID: 31206829
- PSD-95 protects synapses from β-amyloid. | Dore, K., et al. 2021. Cell Rep. 35: 109194. PMID: 34077732
- Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. | Kretschmer, BD., et al. 1995. Eur J Pharmacol. 280: 37-45. PMID: 7498252
- Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. | Bartlett, RD., et al. 1998. Neuropharmacology. 37: 839-46. PMID: 9776380
- Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems | Fontana, A. C. K. 2018. Biochemical Approaches for Glutamatergic Neurotransmission. 130: 169-225.
Inhibitor of:
EAAT, and NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Chlorokynurenic acid sodium salt, 10 mg | sc-291578 | 10 mg | $95.00 | |||
| US: Only available in the US | ||||||
7-Chlorokynurenic acid sodium salt, 50 mg | sc-291578A | 50 mg | $399.00 | |||
| US: Only available in the US | ||||||