Molecular structure of (±)-HIP-A, CAS Number: 227619-64-9
(±)-HIP-A (CAS 227619-64-9)
Alternate Names:
(±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid
Application:
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker
CAS Number:
227619-64-9
Molecular Weight:
172.14
Molecular Formula:
C6H8N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 43 and 8 μM respectively).
(±)-HIP-A (CAS 227619-64-9) References
1. Conti, P., et al. 1999. J. Med .Chem. 42: 4099-4107.2. Funicello, M., et al. 2004. Mol. Pharmacol. 66:522-529.
Inhibitor of:
EAAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-HIP-A, 10 mg | sc-203598 | 10 mg | $131.00 | |||
| US: Only available in the US | ||||||