E2F-5 Activators
E2F-5 Activators represent a diverse group of chemical compounds that either directly or indirectly activate the activity of E2F-5, a crucial transcription factor involved in cell cycle regulation and gene expression. These activators play pivotal roles in influencing E2F-5 expression, thereby impacting various cellular processes. Retinoic Acid (RA) and its isomer 9-cis-Retinoic Acid serve as direct activators of E2F-5. They achieve this by binding to retinoic acid receptors (RARs) and subsequently regulating E2F-5 expression. This activation of E2F-5 contributes to cellular differentiation processes and helps maintain a balanced cell cycle. Several B-vitamins, such as Folic Acid, Vitamin B12 (Cobalamin), Pyridoxal-5-Phosphate (PLP), Thiamine (Vitamin B1), and Riboflavin (Vitamin B2), indirectly activate E2F-5 by participating in one-carbon metabolism. This metabolic pathway provides essential methyl groups for DNA methylation, which in turn influences E2F-5 activity in gene regulation and cell cycle control.
Minerals like Zinc and Copper play a role in indirectly activating E2F-5 by modulating the activity of DNA methyltransferases involved in DNA methylation. This modulation indirectly impacts E2F-5-mediated gene regulation and cell cycle processes. Essential amino acids such as Methionine contribute to E2F-5 activation by participating in one-carbon metabolism and DNA methylation. Methionine's role in supplying methyl groups for DNA modification affects E2F-5-mediated gene regulation and cell cycle control. Niacin (Vitamin B3) is another indirect activator of E2F-5 through its involvement in one-carbon metabolism and DNA methylation pathways. In conclusion, E2F-5 Activators encompass a range of chemical compounds that can directly or indirectly influence E2F-5 activity, impacting various cellular processes, including gene regulation and cell cycle control. These activators play essential roles in maintaining cellular homeostasis and provide valuable insights into the regulation of E2F-5-mediated processes.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid (RA) is a direct activator of E2F-5. It acts by binding to retinoic acid receptors (RARs) and regulating E2F-5 expression, which plays a pivotal role in cell differentiation. RA-induced E2F-5 activation contributes to cellular differentiation processes. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
9-cis-Retinoic Acid is an isomer of Retinoic Acid and a direct activator of E2F-5. It modulates E2F-5 expression through RARs, influencing cell differentiation pathways and contributing to E2F-5 activation. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic Acid is a B-vitamin that can act as an indirect activator of E2F-5 by participating in one-carbon metabolism. This metabolic pathway provides essential methyl groups for DNA methylation, which indirectly influences E2F-5 activity in gene regulation and cell cycle control. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Vitamin B12 is involved in one-carbon metabolism and can indirectly activate E2F-5 by contributing to DNA methylation. Its role in supplying methyl groups for DNA modification impacts E2F-5-mediated gene regulation and cell cycle processes. | ||||||
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $126.00 $372.00 | 7 | |
all-trans Retinal is a direct activator of E2F-5 through its involvement in retinoic acid biosynthesis. It can modulate E2F-5 expression by participating in the generation of active retinoic acid, contributing to cell differentiation and E2F-5 activation. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine is an essential amino acid that indirectly activates E2F-5 by participating in one-carbon metabolism and DNA methylation. Its role in providing methyl groups affects E2F-5-mediated gene regulation and cell cycle control. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
Pyridoxal-5-Phosphate (PLP) is the active form of vitamin B6 and indirectly activates E2F-5 through its involvement in one-carbon metabolism. PLP contributes to DNA methylation, influencing E2F-5-mediated gene regulation and cell cycle processes. | ||||||
Vitamin B1 | 59-43-8 | sc-338735 | 5 g | $611.00 | ||
Thiamine, also known as Vitamin B1, can act as an indirect activator of E2F-5 by participating in one-carbon metabolism. Its role in metabolic pathways influences DNA methylation, impacting E2F-5 activity in gene regulation and cell cycle control. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a trace element that can indirectly activate E2F-5 by modulating the activity of DNA methyltransferases involved in DNA methylation. Zinc's influence on DNA methylation pathways indirectly impacts E2F-5-mediated gene regulation and cell cycle processes. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Riboflavin, also known as Vitamin B2, indirectly activates E2F-5 by participating in one-carbon metabolism. Its role in metabolic pathways provides methyl groups for DNA methylation, influencing E2F-5-mediated gene regulation and cell cycle control. | ||||||