E130120F12Rik Activators
Zfp953, a zinc finger protein, holds a crucial role as a DNA-binding transcription factor with specificity for RNA polymerase II cis-regulatory region sequences. Its predicted functions include enabling DNA-binding transcription factor activity and participating in the regulation of transcription by RNA polymerase II. Active within the nucleus, Zfp953 plays a pivotal role in orchestrating gene expression, linking its activities to critical cellular processes. The target's involvement in RNA polymerase II-mediated transcription suggests a central role in the modulation of gene regulatory networks.
The activation of Zfp953 involves a complex interplay of chemical modulators influencing diverse cellular pathways. These pathways encompass epigenetic modifications, DNA damage response, nucleotide metabolism, and chromatin remodeling. Chemicals such as retinoic acid, cisplatin, and trichostatin A may directly or indirectly up-regulate Zfp953 by impacting its DNA-binding transcription factor activity and RNA polymerase II-specific functions. The intricate involvement of Zfp953 in these pathways underscores its adaptability and responsiveness to various cellular cues. The activation mechanisms highlight the dynamic interplay of epigenetic and genomic processes, demonstrating the nuanced regulation of Zfp953's engagement in transcriptional control within the nucleus. Further exploration of these pathways promises to unveil additional layers of complexity, providing insights into the molecular orchestration directed by Zfp953 in the intricate landscape of gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A derivative, may act as a direct or indirect activator of Zfp953. It influences transcription by RNA polymerase II by binding to retinoic acid response elements, potentially enhancing Zfp953's DNA-binding transcription factor activity. The activation could involve modulation of retinoic acid receptors, leading to increased Zfp953 expression and its subsequent role in the regulation of transcription within RNA polymerase II cis-regulatory regions in the nucleus. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a DNA-damaging agent, may indirectly activate Zfp953. By inducing DNA damage, it triggers cellular responses that can influence the regulation of transcription by RNA polymerase II. This could involve activation of DNA repair pathways, ultimately leading to enhanced Zfp953 activity in binding to RNA polymerase II cis-regulatory regions. Cisplatin's impact on DNA integrity may serve as a signal for the up-regulation of Zfp953 and its subsequent involvement in the nucleus in the context of transcriptional regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, may up-regulate Zfp953 by influencing chromatin remodeling. Through inhibition of histone deacetylases, it could lead to an open chromatin structure favoring Zfp953's binding to RNA polymerase II cis-regulatory regions. This epigenetic modulation may enhance Zfp953's DNA-binding transcription factor activity, promoting its role in the regulation of transcription within the nucleus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a demethylating agent, may indirectly activate Zfp953. By inhibiting DNA methyltransferases, it influences the epigenetic landscape, potentially promoting Zfp953's binding to RNA polymerase II cis-regulatory regions. The demethylation process may lead to increased accessibility of these regions, facilitating Zfp953's engagement in the regulation of transcription by RNA polymerase II, thereby activating its DNA-binding transcription factor activity in the nucleus. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D, a transcription inhibitor, may indirectly activate Zfp953. By inhibiting RNA polymerase II, it could trigger compensatory mechanisms, leading to enhanced Zfp953 expression and activity. The interruption of transcriptional processes may induce cellular responses, promoting Zfp953's involvement in the regulation of transcription within RNA polymerase II cis-regulatory regions in the nucleus. Actinomycin D's impact on the transcriptional machinery could result in the up-regulation of Zfp953 and its subsequent engagement in transcriptional control. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, may up-regulate Zfp953 by influencing chromatin structure. Through inhibition of histone deacetylases, it could lead to an open chromatin environment favoring Zfp953's binding to RNA polymerase II cis-regulatory regions. This epigenetic modulation may enhance Zfp953's DNA-binding transcription factor activity, promoting its involvement in the regulation of transcription within the nucleus. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate, a polyphenol, may act as an indirect activator of Zfp953. It could influence Zfp953 by modulating cellular signaling pathways related to RNA polymerase II-mediated transcription. This might involve activation of specific kinases or transcription factors, leading to enhanced Zfp953 expression and its subsequent role in the regulation of transcription within RNA polymerase II cis-regulatory regions in the nucleus. Epigallocatechin gallate's impact on signaling cascades may contribute to the up-regulation of Zfp953 and its engagement in transcriptional control. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil, an antimetabolite, may indirectly activate Zfp953. By interfering with nucleotide synthesis, it could trigger cellular responses that influence the regulation of transcription by RNA polymerase II. This may involve activation of signaling pathways leading to enhanced Zfp953 expression and its subsequent role in the regulation of transcription within RNA polymerase II cis-regulatory regions in the nucleus. 5-Fluorouracil's impact on nucleotide metabolism may serve as a signal for the up-regulation of Zfp953 and its involvement in transcriptional control. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, a histone deacetylase inhibitor, may up-regulate Zfp953 by influencing chromatin structure. Through inhibition of histone deacetylases, it could lead to an open chromatin environment favoring Zfp953's binding to RNA polymerase II cis-regulatory regions. This epigenetic modulation may enhance Zfp953's DNA-binding transcription factor activity, promoting its involvement in the regulation of transcription within the nucleus. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Sodium valproate, a histone deacetylase inhibitor, may up-regulate Zfp953 by influencing chromatin structure. Through inhibition of histone deacetylases, it could lead to an open chromatin environment favoring Zfp953's binding to RNA polymerase II cis-regulatory regions. This epigenetic modulation may enhance Zfp953's DNA-binding transcription factor activity, promoting its involvement in the regulation of transcription within the nucleus. | ||||||