Dyrk3 Activators
Dyrk3 Activators are a group of chemicals that can enhance the functional activity of Dyrk3, a protein involved in various cellular processes. These compounds primarily work by influencing the adenylate cyclase-cAMP-PKA pathway, a critical cell signaling pathway that Dyrk3 is directly involved in. Forskolin and IBMX, for example, enhance the functional activity of Dyrk3 by activating adenylate cyclase and inhibiting phosphodiesterases respectively, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate Dyrk3.
On the other hand, PGE2, Epinephrine, Isoproterenol, Dopamine, Glucagon, Histamine, Serotonin, Adenosine, and Bimatoprost act by binding to specific receptors. The binding stimulates adenylate cyclase, leading to increased cAMP levels. This series of events, in turn, activates PKA, which can phosphorylate and activate Dyrk3. Rolipram, on the other hand, acts by inhibiting phosphodiesterase 4 (PDE4), resulting in an increase in cAMP levels. This ultimately leads to the activation of PKA and subsequently Dyrk3. The specific receptors involved for these compounds include EP receptors, β-adrenergic receptors, D1-like receptors, glucagon receptors, H2 receptors, 5-HT4, 5-HT6, and 5-HT7 receptors, A2A and A2B receptors, and prostaglandin receptors. The commonality among these Dyrk3 Activators is their ability to influence the adenylate cyclase-cAMP-PKA pathway, leading to the phosphorylation and activation of Dyrk3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA), which can phosphorylate and activate Dyrk3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits phosphodiesterases, leading to an increase in cAMP levels. Increased cAMP activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 binds to EP receptors, stimulating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), causing an increase in cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to β-adrenergic receptors, stimulating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol binds to β-adrenergic receptors, stimulating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to D1-like receptors, stimulating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Glucagon binds to glucagon receptors, stimulating adenylate cyclase activity and increasing cAMP levels. Increased cAMP activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to H2 receptors, stimulating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate Dyrk3. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
3-(2-Aminoethyl)-1H-indol-5-ol (Serotonin) binds to 5-HT4, 5-HT6, and 5-HT7 receptors, stimulating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate Dyrk3. | ||||||