Dyrk3 Antibody (H-11): sc-390532
- Dyrk3 Antibody (H-11) is a mouse monoclonal IgG1 κ Dyrk3 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 188-210 of Dyrk3 of human origin
- Dyrk3 Antibody (H-11) is recommended for detection of Dyrk3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Dyrk3 Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Dyrk3 Antibody (H-11) for WB applications. This reagent is now offered in a bundle with Dyrk3 Antibody (H-11) (see ordering information below).
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Dyrk3 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dyrk3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dyrk3 (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dyrk3, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a crucial role in cellular signaling pathways, particularly in the regulation of neurogenesis and cell differentiation. Dyrk3′s dual-specificity kinase activity enables phosphorylation of both tyrosine and serine/threonine residues, which is essential for modulating various cellular processes. Dyrk3 is strongly expressed in the testis following the onset of spermatogenesis, indicating a significant role in male reproductive development. Expression of Dyrk3 in other tissues, such as the spleen and adrenal gland, is minimal, suggesting a specialized function in reproductive biology. Genes encoding Dyrk2 and Dyrk3 are located on human chromosomes 12 and 1q32, respectively, highlighting evolutionary conservation and importance in mammalian biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dyrk3 Antibody (H-11) References:
- Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. | Guimera, J., et al. 1999. Genomics. 57: 407-18. PMID: 10329007
- DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. | Li, K., et al. 2002. J Biol Chem. 277: 47052-60. PMID: 12356771
- DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. | Zhang, D., et al. 2005. Genomics. 85: 117-30. PMID: 15607427
- Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII. | Kentrup, H., et al. 1996. J Biol Chem. 271: 3488-95. PMID: 8631952
- Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21. | Shindoh, N., et al. 1996. Biochem Biophys Res Commun. 225: 92-9. PMID: 8769099
- Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'. | Song, WJ., et al. 1996. Genomics. 38: 331-9. PMID: 8975710
- Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. | Becker, W., et al. 1998. J Biol Chem. 273: 25893-902. PMID: 9748265
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dyrk3 Antibody (H-11) | sc-390532 | 200 µg/ml | $316.00 | |||
Dyrk3 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-526169 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dyrk3 Antibody (H-11) AC | sc-390532 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Dyrk3 Antibody (H-11) HRP | sc-390532 HRP | 200 µg/ml | $316.00 | |||
Dyrk3 Antibody (H-11) FITC | sc-390532 FITC | 200 µg/ml | $330.00 | |||
Dyrk3 Antibody (H-11) PE | sc-390532 PE | 200 µg/ml | $343.00 | |||
Dyrk3 Antibody (H-11) Alexa Fluor® 488 | sc-390532 AF488 | 200 µg/ml | $357.00 | |||
Dyrk3 Antibody (H-11) Alexa Fluor® 546 | sc-390532 AF546 | 200 µg/ml | $357.00 | |||
Dyrk3 Antibody (H-11) Alexa Fluor® 594 | sc-390532 AF594 | 200 µg/ml | $357.00 | |||
Dyrk3 Antibody (H-11) Alexa Fluor® 647 | sc-390532 AF647 | 200 µg/ml | $357.00 | |||
Dyrk3 Antibody (H-11) Alexa Fluor® 680 | sc-390532 AF680 | 200 µg/ml | $357.00 | |||
Dyrk3 Antibody (H-11) Alexa Fluor® 790 | sc-390532 AF790 | 200 µg/ml | $357.00 | |||
Dyrk3 (H-11) Neutralizing Peptide | sc-390532 P | 100 µg/0.5 ml | $68.00 |