DUB1 Inhibitors
DUB1 inhibitors are a class of chemical compounds designed to specifically inhibit the activity of the deubiquitinating enzyme DUB1, which plays a role in the regulation of the ubiquitin-proteasome system (UPS). DUB1 is involved in the removal of ubiquitin moieties from target proteins, a critical process that influences protein stability, localization, and degradation. Ubiquitination typically marks proteins for degradation by the proteasome, but DUB1 acts by reversing this process, thereby rescuing proteins from degradation. By removing ubiquitin chains from specific substrates, DUB1 can regulate the turnover of key cellular proteins involved in various processes such as cell cycle regulation, signal transduction, and stress responses. Inhibiting DUB1 disrupts its deubiquitination activity, leading to altered protein dynamics and potentially enhanced degradation of its target substrates.
Structurally, DUB1 inhibitors are often designed to interact with the enzyme's catalytic domain, blocking its ability to hydrolyze the isopeptide bond between ubiquitin and the substrate protein. These inhibitors may function through competitive mechanisms by directly occupying the active site, or they may act allosterically by inducing conformational changes that reduce the enzyme's overall activity. The inhibition of DUB1 provides researchers with a tool to study the specific role of deubiquitination in cellular regulation and protein homeostasis. By understanding how DUB1 inhibition affects the fate of ubiquitinated proteins, scientists can gain insights into the broader mechanisms of protein turnover and stability, as well as the regulatory networks that control cell function. The study of DUB1 inhibitors contributes to a deeper understanding of how the ubiquitin-proteasome system maintains cellular balance and responds to various environmental and internal cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
Deubiquitinase inhibitor affecting USP36. WP1130 disrupts the ubiquitin-specific protease family, preventing deubiquitination of c-Myc and thereby destabilizing this oncoprotein. This destabilization leads to reduced c-Myc levels and inhibits USP36's role in stabilizing c-Myc. | ||||||
P005091 | 882257-11-6 | sc-478535 | 10 mg | $155.00 | ||
USP inhibitor disrupting ubiquitin-specific proteases. P5091 inhibits USP36, preventing the deubiquitination of c-Myc. The inhibition of c-Myc stabilization hampers the oncoprotein's activity, indirectly inhibiting USP36's role in promoting c-Myc stability. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Autophagy inhibitor affecting USP36. Spautin-1 disrupts the activation of autophagy, a process regulated by USP36. The inhibition of autophagy indirectly impacts USP36 by disrupting its regulatory role in this cellular process. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
Deubiquitinase inhibitor influencing USP36. NSC697923 disrupts the activity of USP36, inhibiting its deubiquitination of c-Myc. This inhibition results in decreased c-Myc levels, indirectly inhibiting USP36's role in stabilizing the oncoprotein. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
Ubiquitin-specific protease inhibitor affecting USP36. IU1 inhibits USP36, preventing the deubiquitination of c-Myc. The destabilization of c-Myc leads to an indirect inhibition of USP36, as its role in c-Myc stabilization is disrupted by the action of IU1. | ||||||
UCH-L1 Inhibitor Inhibitor | 668467-91-2 | sc-356182 | 10 mg | $204.00 | 1 | |
Deubiquitinase inhibitor impacting USP36. LDN-57444 disrupts the ubiquitin-specific protease family, inhibiting USP36's deubiquitination of c-Myc. This leads to the destabilization of c-Myc, indirectly inhibiting USP36 by disrupting its role in c-Myc stabilization. | ||||||
Pimozide | 2062-78-4 | sc-203662 | 100 mg | $104.00 | 3 | |
Autophagy inhibitor impacting USP36. Pimozide disrupts the activation of autophagy, a process regulated by USP36. The inhibition of autophagy indirectly impacts USP36 by disrupting its regulatory role in this cellular process. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
Broad-spectrum deubiquitinase inhibitor affecting USP36. PR-619 inhibits USP36, disrupting its deubiquitination activity. This inhibition leads to the destabilization of c-Myc, indirectly inhibiting USP36 by interfering with its role in c-Myc stabilization. | ||||||