DSC1 Inhibitors
Chemical inhibitors of DSC1 encompass a diverse group of compounds that potentially influence DSC1 activity indirectly through the modulation of cellular signaling pathways, cytoskeletal dynamics, and cell adhesion mechanisms. The primary mechanism of action for these inhibitors involves targeting key signaling molecules and pathways associated with cell adhesion and cytoskeletal organization. Compounds like Staurosporine, LY294002, Bisindolylmaleimide I, Genistein, U0126, PD98059, and Y-27632 affect various signaling pathways such as protein kinases, PI3K/AKT, MAPK/ERK, and ROCK. By modulating these pathways, these inhibitors can indirectly impact DSC1 function, given its role in maintaining cell adhesion and integrity in epithelial tissues.
The second group of compounds includes agents that influence cellular architecture and adhesion structures. Nocodazole, Blebbistatin, Thapsigargin, and Calphostin C target microtubule dynamics, myosin II, calcium signaling, and protein kinase C, respectively. These alterations in cellular architecture, contractility, and signaling can indirectly affect the function and stability of DSC1 in desmosomes, which are critical for cell-cell adhesion in epithelial cells.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Protein kinase inhibitor; can indirectly affect DSC1 by altering kinase-mediated signaling pathways involved in cell adhesion. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor; can influence DSC1 by modulating PI3K/AKT signaling pathways that are involved in cell survival and adhesion. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
PKC inhibitor; can impact DSC1 function by affecting protein kinase C (PKC) mediated cellular processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural compound with anti-inflammatory properties; can potentially affect DSC1 by modulating cell signaling and adhesion pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor; might influence DSC1 by targeting tyrosine kinase-dependent signaling pathways in epithelial cells. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule depolymerizing agent; can potentially affect DSC1 by disrupting cellular architecture and adhesion structures. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Myosin II inhibitor; might impact DSC1 by influencing cellular contractility and adhesion. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor; can affect DSC1 by modulating the MAPK/ERK pathway, which is involved in cell adhesion and signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
SERCA inhibitor; can influence DSC1 by altering calcium signaling, which is critical for desmosome function. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
PKC inhibitor; might impact DSC1 by affecting protein kinase C mediated signaling and cellular adhesion. | ||||||