Doxl2 Activators
Doxl2, encoding the diamine oxidase-like protein 2, is predicted to have copper ion binding activity and is involved in amine metabolic processes. Operating in the plasma membrane, it shares orthology with human AOC1. Activation of Doxl2 is intricately regulated by various chemical activators. Copper sulfate directly activates Doxl2 by providing essential copper ions, enhancing its diamine oxidase activity and catalyzing the oxidation of primary amines. Substrates like histamine, L-ornithine, and putrescine directly engage in the enzymatic reaction, exemplifying direct activation by triggering Doxl2's catalytic cascade in amine metabolism.
Indirect activators such as pyridoxal phosphate and sodium benzoate modulate Doxl2 by serving as cofactors and influencing amine metabolic processes, respectively. Chemicals like cimetidine and methylene blue indirectly amplify Doxl2's activity by modulating histamine levels and redox processes. This comprehensive understanding of Doxl2's activation provides insights into its crucial role in amine metabolic processes and highlights the intricate regulatory mechanisms involving direct and indirect chemical interactions. These activations emphasize Doxl2's significance in cellular processes, shedding light on potential avenues for further exploration in the context of amine metabolism and related pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper sulfate directly activates Doxl2 by providing essential copper ions. The bound copper enhances Doxl2's diamine oxidase activity, facilitating the oxidation of primary amines. This direct activation promotes the catalytic function of Doxl2 in amine metabolic processes. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal-5-phosphate indirectly activates Doxl2 by serving as a cofactor. It forms a complex with Doxl2, enabling the efficient binding of primary amines. This interaction enhances the catalytic efficiency of Doxl2, promoting its diamine oxidase activity in amine metabolic processes. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine acts as a substrate for Doxl2, directly participating in the enzymatic reaction. As a primary amine, histamine is oxidized by Doxl2, demonstrating its role as a direct activator that triggers the catalytic activity of Doxl2 in the oxidation of primary amines. | ||||||
Benzoic acid | 65-85-0 | sc-203317 sc-203317A sc-203317B | 25 g 100 g 500 g | $20.00 $51.00 $61.00 | ||
Benzoic acid indirectly activates Doxl2 by influencing the amine metabolic process. Its presence enhances the substrate pool for Doxl2, providing additional primary amines for oxidation. This indirect activation stimulates Doxl2's diamine oxidase activity in amine metabolism. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine indirectly activates Doxl2 by influencing histamine levels. By inhibiting histamine receptors, cimetidine reduces histamine degradation, increasing its availability as a substrate for Doxl2. This indirect activation amplifies Doxl2's diamine oxidase activity in histamine metabolism. | ||||||
Ornithine | 70-26-8 | sc-507552 | 100 mg | $77.00 | ||
L-Ornithine acts as a substrate for Doxl2, directly participating in the enzymatic reaction. The oxidation of L-ornithine by Doxl2 exemplifies its direct activation, triggering the enzymatic cascade that leads to enhanced diamine oxidase activity and participation in amine metabolic processes. | ||||||
Dibromomethane | 74-95-3 | sc-257323 | 1 g | $23.00 | ||
Dibromomethane serves as a substrate for Doxl2, directly engaging in the enzymatic process. Its oxidation by Doxl2 showcases direct activation, stimulating the diamine oxidase activity of Doxl2 in primary amine metabolism. This direct involvement supports the critical role of Doxl2 in amine metabolic processes. | ||||||
Sodium benzoate | 532-32-1 | sc-251009 | 250 g | $21.00 | ||
Sodium benzoate indirectly activates Doxl2 by modulating the amine metabolic process. As a precursor of benzoic acid, it contributes to the pool of primary amines available for Doxl2. This indirect activation amplifies Doxl2's diamine oxidase activity, promoting its role in amine metabolic pathways. | ||||||
Cadaverine | 462-94-2 | sc-239454 | 10 ml | $216.00 | ||
Cadaverine acts as a substrate for Doxl2, directly participating in the enzymatic reaction. The direct activation of Doxl2 by cadaverine exemplifies its role in the oxidation of primary amines. This direct engagement supports the involvement of Doxl2 in amine metabolic processes, showcasing its catalytic function. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Methylene blue indirectly activates Doxl2 by modulating redox processes. Acting as an electron acceptor, it influences the enzymatic redox cycle, indirectly supporting Doxl2's diamine oxidase activity. This indirect activation enhances Doxl2's role in primary amine metabolism and redox-related processes. | ||||||