Dos Inhibitors
Chemical inhibitors of Dos provide various methods to impede its function by targeting different signaling pathways and enzymatic activities that are crucial for Dos's role in cellular processes. Staurosporine serves as a non-selective kinase inhibitor, directly thwarting Dos's kinase activity, which is fundamental to its ability to phosphorylate substrates. Similarly, other kinase inhibitors such as PD98059 and U0126 focus on the MEK/ERK pathway, upstream of Dos, to prevent necessary phosphorylation events Dos would normally carry out, thereby impeding its function. The inhibitor SP600125 targets the JNK pathway, which is another signaling route that could influence Dos's activity, and SB203580 specifically inhibits p38 MAP kinase, which is part of the MAPK pathway integral to Dos's function.
On another front, LY294002 and Wortmannin are both potent PI3K inhibitors; they obstruct the PI3K-mediated signaling processes that Dos requires for proper regulation and function. Rapamycin disrupts the mTOR pathway, which is a critical signaling cascade that Dos is part of, and its inhibition leads to a decrease in Dos downstream signaling activity. Dasatinib, being a broad-spectrum tyrosine kinase inhibitor, can impede Dos by targeting various kinases involved in Dos's regulation and activation. The Src family kinases, which are implicated in Dos's activation, are selectively inhibited by PP2, thereby diminishing Dos's activity. Y-27632, a ROCK kinase inhibitor, can attenuate Dos function by disrupting actin dynamics, which are important for Dos signaling. Lastly, PF-562271 targets FAK and Pyk2, whose signaling pathways contribute to the overall activity and regulation of Dos, by inhibiting these kinases, PF-562271 obstructs the cell adhesion and migration processes Dos relies on.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. It can inhibit Dos by blocking its kinase activity, as Dos is a protein kinase whose function relies on its ability to phosphorylate substrates. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). Dos function can be inhibited by LY294002 as the PI3K pathway is involved in the regulation of Dos, and PI3K signaling is crucial for the activation and function of Dos. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can inhibit Dos by disrupting the mTOR signaling pathway, which Dos is a part of. This disruption can inhibit the downstream signaling required for Dos activation and function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK). Dos activity can be inhibited by PD98059 through the inhibition of the MEK/ERK pathway, which is required for Dos function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of ERK, a downstream target of Dos. By inhibiting MEK, U0126 indirectly inhibits Dos function by blocking the necessary phosphorylation events that Dos would carry out. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), and by inhibiting JNK, it can inhibit Dos by disrupting the JNK signaling pathways that are involved in the regulation and function of Dos. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor like LY294002. It can inhibit Dos by preventing PI3K-mediated signaling processes required for the proper function and regulation of Dos. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Dos, being a part of the MAPK pathway, can be inhibited by SB203580 as it interferes with the p38 MAPK signaling cascade that is crucial for Dos function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Dos can be inhibited by PP2 through the inhibition of Src family kinases that participate in the activation and regulation of Dos. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor that can inhibit Dos by targeting multiple kinases that are involved in the regulation and activation of Dos. | ||||||