Dnmt3a Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SGI-1027 | 1020149-73-8 | sc-473875 | 10 mg | $213.00 | ||
SGI-1027 is a quinoline compound that inhibits DNA methyltransferases, including Dnmt3a. It acts by binding to the catalytic site of the enzyme, preventing its interaction with the substrate. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that incorporates into DNA and RNA. Once integrated, it inhibits DNA methyltransferases, including Dnmt3a, leading to demethylation and reactivation of silenced genes. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is another nucleoside analog similar to 5-Azacytidine. It gets incorporated into DNA and acts as a covalent inhibitor of DNA methyltransferases, leading to decreased activity of enzymes like Dnmt3a. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a non-nucleoside inhibitor of DNA methyltransferases. It specifically inhibits Dnmt3a by blocking its active site without causing DNA damage. | ||||||
Procainamide hydrochloride | 614-39-1 | sc-202297 | 10 g | $53.00 | ||
Procainamide has been found to inhibit DNA methylation. It can inhibit Dnmt3a by interacting with its catalytic domain, leading to reduced methylation activity. | ||||||
1-Hydrazinophthalazine Hydrochloride | 304-20-1 | sc-206167 | 10 g | $280.00 | ||
Studies show Hydralazine has inhibitory effects on DNA methyltransferases. It can inhibit Dnmt3a, leading to the reversal of aberrant methylation patterns observed in certain pathological conditions. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine is a cytidine analog that acts as an inhibitor of DNA methyltransferases. It gets incorporated into DNA and forms a covalent complex with Dnmt3a, thereby inhibiting its activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has been found to inhibit DNA methyltransferases. It can down-regulate Dnmt3a activity, although its precise mechanism in relation to Dnmt3a remains to be elucidated. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a specific inhibitor of G9a histone methyltransferase, but it also shows inhibitory effects on Dnmt3a. Its mechanism might involve disruption of Dnmt3a's interaction with specific cofactors essential for its activity. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Although primarily known as an inhibitor of the SUV39H1 histone methyltransferase, chaetocin also shows inhibition of DNA methyltransferases. It can down-regulate Dnmt3a activity, potentially by modulating the cellular redox state, which is crucial for the function of these enzymes. | ||||||