DNAHC7A Inhibitors
DNAHC7A inhibitors comprise a diverse group of compounds that interact with the dynein motor protein complex, more specifically with the axonemal heavy chain 7A component. This particular subset of inhibitors does not target DNAHC7A directly but exerts its effect by modulating the microtubule tracks on which dynein motors operate or by altering the ATPase activity that powers the dynein motor function. These compounds have been identified to have affinities for various structural and functional elements of the microtubule-dynein system, demonstrating a broad range of interactions from microtubule stabilization to the prevention of microtubule polymerization. The first group within this class includes agents such as Nocodazole and Vinblastine, which bind to tubulin, the building block of microtubules, thereby preventing its polymerization and leading to microtubule depolymerization.
This disruption of the microtubule network can inhibit DNAHC7A function by eliminating the structural framework necessary for its motor activity. In contrast, stabilizing agents like Paclitaxel and Epothilone B work oppositely by enhancing the polymerization of tubulin into microtubules and then stabilizing these structures to such an extent that the dynamicity required for normal dynein function is lost. Such stabilized microtubules can no longer provide the necessary platform for DNAHC7A to carry out its movement, effectively inhibiting its action. Another aspect of this chemical class targets the motor domain of the dynein protein. Ciliobrevin D, for example, is known to inhibit the ATPase activity of dynein, which is crucial for its movement along the microtubule tracks. By preventing ATP hydrolysis, these inhibitors stop the conformational changes needed for dynein to "walk" along microtubules, thus halting the function of DNAHC7A. Additionally, some compounds within this class may influence the regulation of DNAHC7A by interfering with the signaling pathways or phosphorylation events that modulate dynein motor activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ciliobrevin D | 1370554-01-0 | sc-507482 | 10 mg | $413.00 | ||
This small molecule inhibits the ATPase activity of cytoplasmic dynein, potentially affecting DNAHC7A's function indirectly by similar mechanisms of action. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule-depolymerizing agent that could inhibit DNAHC7A by disrupting the microtubule tracks necessary for its motor activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and may indirectly inhibit DNAHC7A by reducing microtubule dynamics essential for proper dynein motor function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Binds to tubulin and inhibits microtubule formation, potentially inhibiting DNAHC7A by preventing its interaction with microtubule tracks. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Another microtubule-stabilizing agent that could restrict DNAHC7A activity by affecting the flexibility of microtubules. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds tubulin, preventing its polymerization and thus could inhibit DNAHC7A by disrupting microtubule dynamics. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Interacts with microtubules and disrupts mitotic spindle formation, which could indirectly affect DNAHC7A function by altering microtubule dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
While primarily known to inhibit actin polymerization, its alterations of cytoskeletal dynamics could indirectly impact microtubule-associated processes and dynein function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
An inhibitor of kinesin Eg5 which could affect microtubule dynamics and indirectly affect dynein function, including DNAHC7A. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
A microtubule dynamics inhibitor that may indirectly affect DNAHC7A through its role in inhibiting the growth phase of microtubules. | ||||||