DNAH11 Activators
DNAH11 activators would represent a class of compounds focused on modulating the activity of DNAH11, or Dynein Axonemal Heavy Chain 11, which is an enzyme that belongs to the dynein protein family. Dyneins are motor proteins that convert chemical energy from ATP hydrolysis into mechanical work, which is crucial for various cellular processes, including ciliary and flagellar movement. DNAH11 is specifically implicated in the movement of cilia, cellular organelles that play key roles in fluid movement across cell surfaces, and sensory functions.
Direct activators of DNAH11 interact with the protein's ATPase domain or other critical regions that are involved in its motor activity. By binding to these sites, direct activators could enhance the enzyme's affinity for ATP or increase the efficiency of ATP hydrolysis, leading to a more robust motor function. This may result in increased ciliary beat frequency or improved ciliary movement, which are essential for the proper function of ciliated cells. Indirect activators, on the other hand, might not interact with DNAH11 directly but could influence factors that regulate its expression, stability, assembly, or integration into ciliary structures. These could include signaling molecules that upregulate the expression of DNAH11, chaperones that assist in its proper folding and assembly, or other cellular components that participate in the formation and maintenance of functional cilia.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC). DNAH11, a dynein protein, can be influenced by intracellular Ca2+ levels which are regulated by PKC. Increased PKC activity through PMA can indirectly modulate DNAH11 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, leading to Protein Kinase A (PKA) activation. PKA regulates microtubule-based cellular processes, which are critical for dynein proteins like DNAH11. Thus, Forskolin can indirectly enhance the function of DNAH11. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates the retinoic acid receptor (RAR). RAR can modulate gene expression, including genes involved in microtubule dynamics. As DNAH11 is a microtubule-dependent motor protein, Retinoic Acid can indirectly influence its function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist. Beta-adrenergic signaling is known to influence intracellular Ca2+ levels, which can indirectly modulate the function of dynein proteins like DNAH11. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase (HDAC) inhibitor. By promoting histone acetylation, it enhances the accessibility of transcription factors to promoter regions, which can indirectly increase the transcription of DNAH11. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferase. By preventing DNA methylation, it can promote the expression of genes including DNAH11, if its promoter region is normally methylated. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a regulator of cell growth and proliferation. mTOR signaling can influence microtubule dynamics, and thus indirectly modulate the function of dynein proteins like DNAH11. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus. If DNAH11 is processed through this pathway, Brefeldin A may lead to an increased accumulation of DNAH11 in the cells. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and prevents their depolymerization. As DNAH11 is a microtubule-dependent motor protein, Taxol can indirectly modulate its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics by inducing microtubule depolymerization. This can indirectly influence the function of DNAH11, as it relies on microtubules for its motor activity. | ||||||