DNA Ligase III Activators

The chemical class DNA Ligase III Activators encompasses these compounds, which indirectly modulate the activity of DNA Ligase III through various cellular pathways. Olaparib, a PARP inhibitor, can increase DNA damage, which may subsequently upregulate DNA repair pathways involving DNA Ligase III. Inhibitors of ATM and ATR kinases, such as KU-55933 and VE-821, respectively, can enhance DNA Ligase III activity as part of a broader cellular response to DNA damage.

HDAC inhibitors like Vorinostat, and HSP90 inhibitors such as 17-AAG, influence chromatin remodeling and protein stability, potentially affecting the efficiency of DNA Ligase III in DNA repair processes. GSK-3 inhibitors (e.g., LiCl), mTOR inhibitors (e.g., Rapamycin), and PI3K inhibitors (e.g., LY294002) target key cellular pathways and stress responses, which could indirectly influence DNA Ligase III's role in DNA repair. Furthermore, DNA-PK inhibitors like NU7441 and checkpoint kinase inhibitors such as AZD7762, affect DNA repair dynamics and cell cycle regulation, potentially enhancing DNA Ligase III activity. NAD+ precursors like Nicotinamide riboside and NRF2 activators such as Sulforaphane contribute to the modulation of DNA repair mechanisms, suggesting the potential for indirect enhancement of DNA Ligase III's activity.