DLC-1 Activators
DLC-1 activators belong to a class of molecules that play a crucial role in the regulation of cellular processes related to cell adhesion, migration, and cytoskeletal dynamics. The term "DLC-1" stands for "Deleted in Liver Cancer 1," which refers to a specific gene that encodes a protein known as DLC-1. This protein is a member of the RhoGAP (Rho GTPase-activating protein) family and is recognized for its function in controlling the activity of Rho GTPases, which are key regulators of the cell's cytoskeleton and signaling pathways.
DLC-1 activators are substances or mechanisms that enhance the activity or expression of DLC-1 within cells. DLC-1, when activated, functions as a negative regulator of Rho GTPases, particularly RhoA, by promoting their conversion from their active, GTP-bound form to their inactive, GDP-bound form. This regulation is vital for modulating actin cytoskeletal dynamics, cell adhesion, and cell migration. Activation of DLC-1 can lead to decreased cell motility, increased cell adhesion, and alterations in cell shape, which are crucial processes in various cellular contexts, including development, tissue repair, and cancer metastasis. By influencing Rho GTPase activity, DLC-1 activators contribute to the fine-tuning of these cellular processes, ultimately helping to maintain cellular homeostasis and support various physiological functions. In summary, DLC-1 activators play a pivotal role in the intricate molecular machinery that governs cell behavior and cytoskeletal dynamics, contributing to the fundamental processes that underlie normal cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can indirectly enhance the signaling pathways where DLC-1 is involved. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has been shown to modulate various signaling pathways potentially influencing DLC-1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, LY294002, may indirectly influence DLC-1 activity through the PI3K/AKT pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, Rapamycin might indirectly affect DLC-1 activity through the mTOR signaling pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
This inhibitor of the TGF-β receptor may influence pathways associated with DLC-1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, SP600125, may indirectly influence DLC-1 signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor, PD98059, can indirectly affect DLC-1 activity through the MAPK/ERK pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, Wortmannin may influence DLC-1 activity indirectly through the PI3K/AKT pathway. | ||||||