DHRS9 Activators
DHRS9 Activators are chemical compounds that directly or indirectly enhance the functional activity of the DHRS9 protein, primarily through the retinoid signaling pathway. By binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), these compounds impact retinoid signaling, indirectly enhancing the activity of DHRS9. As DHRS9 is a critical enzyme involved in the metabolism of retinol to retinoic acid, activating the retinoid signaling pathway and increasing the availability of substrates for DHRS9 can enhance its activity.
Each of these compounds interacts with the retinoid signaling pathway, either by binding to RARs or RXRs, or by serving as substrates or analogs of retinoids. The retinoids and retinoid analogs, such as All-trans Retinoic Acid (ATRA), Isotretinoin, and Tazarotene, activate RARs and RXRs, influencing retinoid signaling. In turn, this impacts the functionality of DHRS9, as it is a critical component of the retinoid metabolism pathway. Othercompounds, like Bexarotene and Alitretinoin, selectively bind and activate RXRs, thereby also influencing retinoid signaling and subsequently enhancing the activity of DHRS9. Synthetic retinoids like Arotinoid, Etretinate, and Fenretinide function in a similar manner, binding to RARs and influencing retinoid signaling, which impacts DHRS9's activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA is a metabolite of vitamin A (retinol) and activates retinoic acid receptors (RARs). DHRS9 is involved in the metabolism of retinol to retinoic acid, so ATRA can enhance its activity by substrate availability. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis Retinoic Acid is a natural isomer of ATRA. It activates both RARs and RXRs. By influencing these receptors, it can enhance the activity of DHRS9 through substrate availability. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
Isotretinoin is a retinoid that impacts retinoid signaling. As DHRS9 is involved in retinoid metabolism, Isotretinoin can enhance its activity through substrate availability and pathway engagement. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Tazarotene is a retinoid prodrug converted to its active form by ester hydrolysis. It can bind to RARs and influence retinoid signaling, thereby enhancing DHRS9 activity. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $151.00 | 1 | |
Acitretin is a retinoid that binds to RARs and influences retinoid signaling. As DHRS9 is involved in retinoid metabolism, Acitretin can enhance its activity through substrate availability and pathway engagement. | ||||||
Adapalene | 106685-40-9 | sc-203803 sc-203803A | 10 mg 50 mg | $66.00 $332.00 | 2 | |
Adapalene is a retinoid-like compound that binds to specific RARs and influences retinoid signaling. As DHRS9 is involved in retinoid metabolism, Adapalene can enhance its activity through substrate availability. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Bexarotene is a retinoid that selectively binds and activates RXRs, influencing retinoid signaling. DHRS9, involved in retinoid metabolism, can have its activity enhanced by Bexarotene's action. | ||||||
TTNPB | 71441-28-6 | sc-203303 sc-203303A sc-203303B | 10 mg 25 mg 50 mg | $210.00 $347.00 $640.00 | 20 | |
Arotinoid is a synthetic retinoid that binds to RARs and influences retinoid signaling. As DHRS9 is involved in retinoid metabolism, Arotinoid can enhance its activity by providing substrate. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide is a synthetic retinoid derivative that influences retinoid signaling. DHRS9, involved in retinoid metabolism, can have its activity enhanced by Fenretinide's action. | ||||||