DEP-1 Inhibitors
DEP-1 inhibitors encompass a diverse collection of compounds meticulously designed to interact with and modulate the activity of DEP-1, a receptor-type protein tyrosine phosphatase known as protein tyrosine phosphatase receptor type J (PTPRJ). DEP-1 plays a significant role in the regulation of various cellular processes, including cell growth, differentiation, adhesion, and migration. Inhibitors within this class are strategically developed to exert influence on DEP-1, altering its enzymatic activity and subsequently impacting cellular signaling pathways and functions associated with this phosphatase.
The mechanistic array through which DEP-1 inhibitors exert their effects encompasses an assortment of strategies. Central to their function is the ability to bind to the active site or substrate-binding region of DEP-1. This binding interaction disrupts the phosphatase's catalytic capacity, leading to a hindrance in its capacity to dephosphorylate target proteins. Consequently, downstream signaling pathways that govern vital cellular processes are subject to modulation. Structurally, DEP-1 inhibitors exhibit a broad diversity of chemical architectures. This diversity ranges from small organic molecules with specific binding affinities to larger peptidomimetic compounds that mimic the substrate-binding regions of DEP-1. The structural versatility within this class allows for tailored interactions that ultimately impact DEP-1's enzymatic actions. These inhibitors collectively provide valuable tools for understanding DEP-1's role in cellular processes. Their specific mechanisms offer insights into DEP-1's substrate interactions, and their application can contribute to delineating DEP-1-mediated signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium stibogluconate | 16037-91-5 | sc-202815 | 1 g | $188.00 | 6 | |
Originally developed as an antiparasitic agent, sodium stibogluconate has been investigated for its inhibitory effects on DEP-1 and other protein tyrosine phosphatases. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
NSC-87877 is a selective small molecule inhibitor of DEP-It can bind to the catalytic site of DEP-1 and inhibit its phosphatase activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Orthovanadate compound acting as a general protein tyrosine phosphatase (PTP) inhibitor, including DEP-1. Sodium Orthovanadate disrupts DEP-1 function by inhibiting its phosphatase activity, resulting in the modulation of DEP-1-regulated signaling pathways and cellular responses. | ||||||
BVT 948 | 39674-97-0 | sc-203536 sc-203536A | 10 mg 50 mg | $163.00 $663.00 | 2 | |
Small molecule inhibitor of DEP-1, affecting its phosphatase activity. BVT-948 selectively targets DEP-1, disrupting its ability to dephosphorylate specific substrates. This inhibition leads to altered phosphorylation patterns in downstream signaling molecules, influencing cellular processes regulated by DEP-1. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Alkylphospholipid compound with inhibitory effects on DEP-1. Perifosine modulates DEP-1 activity by interfering with its phosphatase function. The inhibition of DEP-1 by Perifosine results in the modulation of cellular signaling pathways, influencing downstream events and cellular responses. | ||||||
PX-478 | 685898-44-6 | sc-507409 | 10 mg | $175.00 | ||
Inhibitor of DEP-1 with potential anti-tumor effects. PX-478 modulates DEP-1 activity, affecting its phosphatase function. The inhibition of DEP-1 by PX-478 results in altered dephosphorylation events, influencing cellular signaling pathways and contributing to its anti-proliferative effects. | ||||||
7β-Hydroxy Cholesterol | 566-27-8 | sc-210655 | 1 mg | $250.00 | 2 | |
Natural product inhibiting DEP-1. 7beta-Hydroxycholesterol modulates DEP-1 activity, potentially through interaction with its catalytic domain. This inhibition leads to altered phosphorylation patterns in downstream signaling molecules, influencing cellular processes regulated by DEP-1. | ||||||
L-Tyrosine | 60-18-4 | sc-473512 sc-473512A sc-473512B sc-473512C | 100 g 250 g 1 kg 5 kg | $52.00 $213.00 $1670.00 $8328.00 | 1 | |
Competitive inhibitor targeting DEP-1 by mimicking substrate phosphotyrosine residues. Phosphotyrosine interferes with the catalytic domain of DEP-1, preventing its dephosphorylation activity. This competitive inhibition results in the modulation of cellular signaling pathways and downstream events regulated by DEP-1. | ||||||