BVT 948 CAS: 39674-97-0
MF: C14H11NO3
MW: 241.25
A non-competitive protein tyrosine phosphatase inhibitor.

BVT 948 (CAS 39674-97-0)

BVT 948 | CAS 39674-97-0 is rated 5.0 out of 5 by 2.
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Alternate Names: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
Application: BVT 948 is a non-competitive protein tyrosine phosphatase inhibitor
CAS Number: 39674-97-0
Purity: ≥98%
Molecular Weight: 241.25
Molecular Formula: C14H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BVT 948 is a non-competitive PTP (protein tyrosine phosphatase) inhibitor. This compound enhances insulin signalling and insulin tolerance in ob/ob mice. BVT 948 displays irreversible inhibition via catalysis of hydrogen peroxide-dependent oxidation of PTP. BVT 948 is an inhibitor of CYP.


References

1. Liljebris, C., et al. 2004. J. Pharmacol. Exp. Ther. 309: 711-719. PMID: 14747616 [

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mM), and DMSO (50 mM). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
183.73° C (Predicted)
Boiling Point :
~400.8° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
PTPs: IC50 = 0.09 - 1.7 µM; Cytochrome P450 isoforms: IC50 < 10 µM
pK Values :
pKa: 5.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6604934
MDL Number :
MFCD00616487
SMILES :
CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C

Download SDS (MSDS)

Certificate of Analysis

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BVT 948 (CAS 39674-97-0)  Product Citations

See how others have used BVT 948 (CAS 39674-97-0). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29540535  Yu, CH. et al. 2018. Biosci. Rep. 38:

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from BVT 948 was found to inhibit the action of BVT 948 was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated NIH/3T3 cells. -SCBT QC
Date published: 2015-03-21
Rated 5 out of 5 by from This compound serves as an irreversible inhibitor This compound serves as an irreversible inhibitor by inducing oxidation of PTP. -SCBT QC
Date published: 2015-02-05
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