DBX2 Inhibitors
Chemical inhibitors of DBX2 function primarily by modulating the activity of kinases that are responsible for phosphorylating proteins, which in turn, affect the stability and function of DBX2. Alsterpaullone, CHIR99021, LiCl, SB-216763, Kenpaullone, and TDZD-8 are compounds that target GSK-3β, a kinase that when active, can lead to the phosphorylation and potential degradation of proteins associated with DBX2. By inhibiting GSK-3β, these compounds can prevent the phosphorylation that would ordinarily promote the degradation of DBX2 or its regulatory proteins, thus maintaining the inhibition of DBX2 within the cellular environment. Each of these inhibitors operates by engaging with the kinase in a manner that disrupts its catalytic activity, blocking the transfer of a phosphate group to the target proteins of DBX2.
In addition to GSK-3β inhibitors, there are compounds that inhibit cyclin-dependent kinases (CDKs), which also play a role in the phosphorylation of proteins that regulate DBX2 activity. Indirubin-3'-monoxime, Roscovitine, Paullones, 5-Iodotubercidin, and 6-Bromoindirubin-3'-oxime fall into this category. These inhibitors bind to CDKs, preventing them from phosphorylating their substrates, which can include proteins that interact with or regulate DBX2. This inhibition of CDKs results in reduced phosphorylation activity, thereby sustaining the functional inhibition of DBX2. Moreover, Harmine targets DYRK, another kinase implicated in the phosphorylation process. By inhibiting DYRK, Harmine can disrupt the phosphorylation and subsequent regulatory effects on DBX2, contributing to its functional inhibition. These chemicals, through their targeted interactions with kinases, create a blockade in the phosphorylation cascade that is necessary for the proper function and stability of DBX2.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone inhibits GSK-3β, a kinase that phosphorylates and potentially destabilizes DBX2, leading to its functional inhibition by promoting its degradation. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
Indirubin-3'-monoxime is a known inhibitor of cyclin-dependent kinases (CDKs) which, when active, can contribute to the stabilization and activity of DBX2 by phosphorylating proteins that interact with DBX2. Inhibition of CDKs can therefore result in the destabilization and functional inhibition of DBX2. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 is a potent inhibitor of GSK-3β. By inhibiting GSK-3β, it can prevent the phosphorylation and subsequent degradation of DBX2, which would maintain its inhibition within the cellular context. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK-3β, which is known to phosphorylate and influence the stability of various proteins, including DBX2. Inhibition by LiCl can lead to the accumulation of non-functional DBX2 due to improper phosphorylation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine selectively inhibits CDKs, which can lead to reduced phosphorylation and activity of proteins involved in the regulation of DBX2, thus functionally inhibiting DBX2. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 inhibits GSK-3β, which is involved in the phosphorylation of proteins that may be necessary for DBX2 function. By inhibiting GSK-3β, SB-216763 can indirectly lead to the functional inhibition of DBX2. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $61.00 $153.00 $231.00 $505.00 | 1 | |
Kenpaullone is another GSK-3β inhibitor that would prevent the phosphorylation of proteins associated with DBX2 function, leading to an inhibition of DBX2. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
5-Iodotubercidin is an adenosine kinase inhibitor that can also inhibit CDKs, potentially leading to reduced phosphorylation and subsequent inhibition of proteins that regulate the activity of DBX2. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Harmine is a potent inhibitor of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK), which can phosphorylate proteins associated with the regulation of DBX2, thereby inhibiting it indirectly. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
6-Bromoindirubin-3'-oxime is a broad-spectrum inhibitor of CDKs and GSK-3β, potentially leading to the inhibition of phosphorylation and stability of DBX2-associated proteins, thereby functionally inhibiting DBX2. | ||||||