DAP kinase Activators
DAP kinase Activators are a diverse set of chemical compounds that modulate various cellular pathways, consequently enhancing the activity of DAP kinase in apoptosis and cytoskeletal reorganization processes. Forskolin, by elevating cAMP levels, activates PKA, which can phosphorylate and activate DAP kinase. Similarly, anisomycin, through activation of the JNK and p38 MAPK pathways, may enhance DAP kinase activity in response to stress signals. Thapsigargin, by increasing cytosolic calcium, activates calmodulin-dependent kinases that can enhance DAP kinase's pro-apoptotic functions. Staurosporine, although a protein kinase inhibitor, may paradoxically activate DAP kinase at low concentrations by altering the activity of kinases that regulate DAP kinase indirectly. The PI3K inhibitor LY294002 could enhance DAP kinase activity by reducing Akt signaling, which normally inhibits pro-apoptotic kinases. Zinc Chloride is proposed to modulate DAP kinase activity by influencing its protein interactions or structural configuration.
Further, the landscape of kinase activity within a cell can be intricately manipulated by compounds such as (S)-Roscovitine, which inhibits cyclin-dependent kinases and may reduce the phosphorylation-dependent inactivation of DAP kinase, thereby promoting its apoptotic function. SP600125 alters stress signaling by inhibiting JNK, which could indirectly lead to the activation of DAP kinase. The epigenetic modulator Trichostatin A could induce expression changes that support DAP kinase activation. Similarly, Cyclosporine A prevents the dephosphorylation of pro-apoptotic factors by inhibiting calcineurin, potentially resulting in the activation of DAP kinase. The MEK1/2 inhibitor U0126 might shift cellular signaling towards pathways that activate DAP kinase. Lastly, Sphingosine-1-phosphate, a bioactive lipid, could mediate the activation of DAP kinase by influencing the stress response and apoptotic signaling. Collectively, these DAP kinase Activators enhance the kinase's functional role in mediating apoptotic and autophagic processes, along with cytoskeletal changes, without the need to increase protein expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride acts as a source of calcium ions, which are necessary cofactors for DAP kinase activation. The presence of calcium ions directly enhances the kinase activity of DAP kinase by binding to its regulatory region, leading to a conformational change that activates the kinase domain. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor known to activate stress-activated protein kinases (SAPKs). Activation of SAPKs can lead to phosphorylation events that promote apoptotic processes, in which DAP kinase is a central player. This indirect effect can enhance the pro-apoptotic function of DAP kinase. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor, but at low concentrations, it can paradoxically activate certain kinases. This activation could potentially enhance the activity of DAP kinase by indirectly influencing signaling pathways involved in apoptosis, where DAP kinase is a key mediator. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. Elevated intracellular calcium can enhance DAP kinase activity as calcium binding is required for its activation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis and can lead to cellular stress responses that involve the activation of DAP kinase-mediated apoptosis. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a serine/threonine phosphatase inhibitor. By preventing the dephosphorylation of proteins, it could maintain or enhance the phosphorylation state of DAP kinase, indirectly increasing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that transports calcium across cell membranes, increasing intracellular calcium concentration, and thereby, could enhance DAP kinase activity by ensuring the availability of calcium ions necessary for its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it could lead to an increased phosphorylation state of cellular proteins, potentially leading to enhanced activity of DAP kinase through indirect mechanisms associated with apoptosis or autophagy, which are processes where DAP kinase is involved. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can cause chromatin remodeling and affect gene expression. This can lead to the activation of stress responses and apoptotic pathways in which DAP kinase is a crucial component, thereby indirectly enhancing the activity of DAP kinase. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). Inhibition of PKC can shift the balance of cellular signaling towards pathways that involve DAP kinase activation, as PKC can have various roles in cell survival and apoptosis regulation. | ||||||