DAF-16 Activators
The chemical activators of DAF-16 are compounds that indirectly influence its activity through modulation of various signaling pathways, particularly the insulin/IGF-1 signaling (IIS) pathway. These activators include a range of compounds from different chemical classes, each impacting cellular signaling mechanisms that ultimately affect DAF-16. Metformin exemplifies a compound that can indirectly activate DAF-16. By inhibiting complex I of the mitochondrial respiratory chain, metformin can influence the IIS pathway, thereby modulating DAF-16 activity. Similarly, resveratrol, a polyphenol found in grapes and berries, activates sirtuins, which are implicated in longevity and stress resistance pathways linked to DAF-16. The mTOR inhibitor rapamycin also indirectly affects DAF-16, demonstrating the interconnectedness of nutrient sensing pathways with longevity and stress response mechanisms.
Other compounds like lithium chloride, known for its effects on GSK-3 inhibition, and 2-Deoxy-D-glucose, a glycolysis inhibitor, further illustrate how diverse chemical compounds can impact signaling pathways relevant to DAF-16 activity. Curcumin, EGCG, and quercetin are examples of naturally occurring compounds with multiple effects on cellular signaling pathways, influencing DAF-16. Moreover, chemicals like salicylate, sodium butyrate, and berberine are known to modulate metabolic and inflammatory pathways, which could have downstream effects on DAF-16 activity. Spermidine, known for its role in cellular autophagy and lifespan extension, represents another avenue through which DAF-16 activity can be indirectly modulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin, an antidiabetic drug, can indirectly activate DAF-16 by inhibiting complex I of the mitochondrial respiratory chain, impacting the IIS pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, is known to activate sirtuins and can indirectly influence DAF-16 activity through these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can impact the IIS pathway and thereby modulate DAF-16 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate certain signaling pathways, such as GSK-3 inhibition, potentially impacting DAF-16. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
This glucose analog can impair glycolysis and indirectly influence signaling pathways affecting DAF-16. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, has been suggested to modulate various signaling pathways, potentially affecting DAF-16. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has multiple effects on signaling pathways that could indirectly influence DAF-16. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylate, an active metabolite of aspirin, can influence various signaling pathways, potentially impacting DAF-16. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, can affect gene expression and might have indirect effects on DAF-16 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine is known to modulate metabolic pathways and may have an indirect effect on DAF-16. | ||||||