Date published: 2026-5-17

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D14Ertd668e Inhibitors

Phf11d, also known as PHD finger protein 11, plays a crucial role in metal ion binding activity and is predominantly located in the nuclear membrane and nucleoplasm. Predicted to be active in the nucleus, Phf11d contributes to gene regulation and cellular processes. To understand the inhibitors of Phf11d, it is essential to explore specific signaling pathways that directly or indirectly influence its activity. One group of inhibitors targets the canonical NF-κB signaling pathway. Chemicals like DMAPT and BAY 11-7082 disrupt this pathway by inhibiting the phosphorylation and subsequent degradation of IκBα, preventing NF-κB translocation to the nucleus. As Phf11d intersects with NF-κB, inhibition of this pathway modulates Phf11d's nuclear functions and gene expression patterns. Another set of inhibitors focuses on the MAPK/ERK pathway. Compounds like U0126 and PD98059 disrupt this pathway by inhibiting MEK1/2. Since Phf11d's function is intricately linked to MAPK/ERK, these inhibitors indirectly influence Phf11d by altering the signaling cascade, leading to changes in its activity and nuclear localization. Additionally, inhibitors targeting the PI3K/AKT pathway, such as LY294002 and Wortmannin, disrupt Phf11d by inhibiting AKT phosphorylation. Given the regulatory role of AKT on Phf11d, these inhibitors serve as indirect modulators, impacting Phf11d's nuclear functions and gene expression patterns. Furthermore, chemicals like SP600125 and SP203580 target the JNK and p38 MAPK pathways, respectively. Inhibition of these pathways indirectly influences Phf11d by altering the signaling dynamics. As Phf11d interacts with JNK and p38 MAPK, these inhibitors lead to changes in Phf11d's activity and nuclear functions. In summary, Phf11d inhibitors act through various pathways, disrupting key signaling cascades and indirectly modulating Phf11d's nuclear functions and gene expression patterns. Understanding the intricate connections between these inhibitors and Phf11d provides insights into potential avenues for further exploration in the field of cellular and molecular biology.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580, a p38 MAPK inhibitor, specifically impedes the p38 MAPK pathway. By suppressing the phosphorylation of p38 MAPK, it indirectly influences PHF11d's activity. The p38 MAPK pathway intersects with PHF11d's signaling, and inhibition of this pathway alters the downstream effects, modulating PHF11d's nuclear functions and gene expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002, a PI3K inhibitor, disrupts the PI3K/AKT pathway. Its action inhibits the phosphorylation of AKT, indirectly affecting PHF11d. As AKT is involved in the regulation of PHF11d, the perturbation of the PI3K/AKT pathway by LY294002 leads to alterations in PHF11d's nuclear functions and gene expression patterns.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125, a JNK inhibitor, specifically targets the JNK signaling pathway. Inhibition of JNK phosphorylation disrupts the pathway, indirectly influencing PHF11d. Since JNK interacts with PHF11d, SP600125 alters the signaling dynamics, leading to changes in PHF11d's activity and nuclear functions.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$62.00
$85.00
$356.00
155
(1)

BAY 11-7082, an inhibitor of NF-κB activation, disrupts the canonical NF-κB signaling pathway. By preventing IκBα phosphorylation, it indirectly affects PHF11d's function. NF-κB intersects with PHF11d, and inhibition of this pathway by BAY 11-7082 modulates PHF11d's nuclear activity, influencing gene expression patterns.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin, a PI3K inhibitor, disrupts the PI3K/AKT pathway. Its inhibition alters the phosphorylation of AKT, indirectly influencing PHF11d. Since AKT is intricately linked to PHF11d regulation, Wortmannin serves as an indirect inhibitor by modulating the PI3K/AKT pathway, leading to changes in PHF11d's nuclear functions and gene expression patterns.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059, a MEK1 inhibitor, disrupts the MAPK/ERK pathway. Its action inhibits the phosphorylation of downstream effectors, indirectly affecting PHF11d. Given the interplay between the MAPK/ERK pathway and PHF11d, PD98059 serves as an indirect inhibitor by modulating the signaling cascade, leading to alterations in PHF11d's activity and nuclear localization.

BMS-345541

445430-58-0sc-221741
1 mg
$312.00
1
(1)

BMS-345541, an inhibitor of the non-canonical NF-κB pathway, disrupts NF-κB signaling. Through inhibition of the phosphorylation of IKKα, it indirectly affects PHF11d's function. Since NF-κB intersects with PHF11d, BMS-345541 modulates PHF11d's nuclear activity, influencing gene expression patterns.

LY 303511

154447-38-8sc-202215
sc-202215A
1 mg
5 mg
$67.00
$278.00
3
(1)

LY303511, a derivative of LY294002, acts as a PI3K inhibitor. Its action disrupts the PI3K/AKT pathway, leading to alterations in the phosphorylation of AKT and indirectly affecting PHF11d. As AKT is intricately linked to PHF11d regulation, LY303511 serves as an indirect inhibitor by modulating the PI3K/AKT pathway, influencing changes in PHF11d's nuclear functions and gene expression patterns.