Cypt4 Inhibitors
Cypt4, or Cryptochrome-4, stands as a crucial player in the intricate machinery orchestrating circadian rhythms. This protein functions as a transcriptional repressor within the molecular clock, forming complexes with other clock-related proteins to modulate the expression of target genes. Specifically, Cypt4 contributes to the regulation of circadian rhythmicity by finely tuning the timing of various physiological processes in response to external environmental cues, particularly light.
Inhibition of Cypt4 involves disrupting its interactions within the circadian regulatory network. The identified chemical inhibitors impact various signaling pathways indirectly linked to Cypt4 function. For instance, BML-275 disrupts AMP-activated protein kinase signaling, indirectly influencing Cypt4 by modulating downstream events in cellular regulatory networks. LY2109761 interferes with Wnt signaling, impacting downstream events that indirectly inhibit Cypt4 function within the cellular regulatory network. Wortmannin, a PI3K inhibitor, modulates the PI3K-Akt pathway, indirectly influencing factors that affect Cypt4 expression and its associated cellular processes. These inhibitors collectively provide a diverse set of tools for researchers to dissect the intricate molecular mechanisms governed by Cypt4. By understanding the specific points of intervention and the interconnected pathways involved, scientists can unravel the complexities of circadian rhythmicity and gain valuable insights into the temporal orchestration of physiological processes orchestrated by Cypt4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
BML-275, an AMPK inhibitor, disrupts AMP-activated protein kinase signaling, indirectly influencing Cypt4 by modulating downstream events in cellular regulatory networks. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $87.00 $270.00 | 9 | |
LY2109761, a GSK-3 inhibitor, interferes with Wnt signaling, impacting downstream events that indirectly inhibit Cypt4 function within the cellular regulatory network. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, interferes with the PI3K-Akt pathway, indirectly modulating factors that affect Cypt4 expression and its associated cellular processes. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42, a JAK2 inhibitor, interferes with JAK-STAT signaling, modulating factors that indirectly hinder Cypt4 expression and its role in cellular regulatory networks. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin1, a dual mTOR inhibitor, disrupts the mTOR signaling pathway, influencing factors that indirectly inhibit Cypt4 and its involvement in cellular regulatory networks. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Trametinib, a MEK inhibitor, disrupts the MAPK pathway, altering downstream events that indirectly hinder Cypt4 function and its involvement in cellular regulatory networks. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, interferes with the p38 pathway, modulating factors that indirectly influence Cypt4 and impede its normal functionality. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin disrupts mTOR signaling, impacting cellular processes connected to Cypt4 expression, leading to an indirect inhibition of the target protein. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide, a Wnt pathway inhibitor, modulates Wnt signaling, influencing downstream events that indirectly inhibit Cypt4 and its involvement in cellular regulatory networks. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082, an NF-κB inhibitor, interferes with the NF-κB signaling pathway, modulating factors that indirectly hinder Cypt4 expression within the cellular regulatory network. | ||||||