Cyp4f40 Activators
Cyp4f40, a member of the cytochrome P450 family, stands as a crucial player in cellular lipid metabolism, specifically involved in the ω-hydroxylation of fatty acids. This enzymatic activity, predominantly expressed in the liver, plays a pivotal role in the breakdown of long-chain fatty acids. By catalyzing the ω-hydroxylation, Cyp4f40 contributes significantly to the regulation of lipid levels within various tissues, emphasizing its importance in maintaining cellular lipid homeostasis. The liver's expression of Cyp4f40 underscores its involvement in the detoxification and clearance of lipophilic compounds, adding another layer to its significance in overall metabolic health. Through its substrate specificity towards fatty acids, Cyp4f40 orchestrates a delicate balance within the intricate network of metabolic pathways, ensuring proper cellular function and energy homeostasis.
The activation of Cyp4f40 is intricately linked to the peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathway. Chemicals identified as direct activators engage PPARγ, initiating a cascade of events that culminate in the upregulation of Cyp4f40 expression. These interactions amplify Cyp4f40 enzymatic activity, solidifying its identity as a direct activator. By modulating PPARγ, the activators, whether through agonistic binding or other molecular interactions, influence the transcriptional regulation of Cyp4f40, demonstrating a tight regulatory connection between the enzyme and the PPARγ pathway. This intricate mechanism of activation underscores the importance of Cyp4f40 in lipid metabolism and highlights the orchestrated interplay between the enzyme and the cellular signaling pathways involved in maintaining lipid homeostasis. In summary, Cyp4f40's vital role in lipid metabolism, coupled with its activation through PPARγ modulation, positions it as a key regulator in maintaining cellular lipid homeostasis, contributing significantly to overall metabolic health.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diethyl phthalate | 84-66-2 | sc-239738 sc-239738A | 25 ml 500 ml | $27.00 $33.00 | ||
Diethyl Phthalate activates Cyp4f40 through PPARγ modulation. Operating as a PPARγ agonist, it stimulates Cyp4f40 expression, initiating a cascade of events that amplify Cyp4f40 enzymatic activity, solidifying its identity as a direct activator of Cyp4f40. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone acts as a direct activator of Cyp4f40 by engaging PPARγ. As a PPARγ agonist, Pioglitazone enhances Cyp4f40 expression, initiating a series of events that amplify Cyp4f40 enzymatic activity, affirming its crucial role as a Cyp4f40 activator. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone serves as a Cyp4f40 activator through PPARγ modulation. Operating as a PPARγ agonist, Rosiglitazone promotes Cyp4f40 expression, triggering a cascade of events that enhance Cyp4f40 enzymatic activity, establishing it as a direct activator of Cyp4f40. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone activates Cyp4f40 via PPARγ modulation. As a PPARγ agonist, Troglitazone stimulates Cyp4f40 expression, initiating a series of events that amplify Cyp4f40 enzymatic activity, confirming its role as a direct activator of Cyp4f40. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid serves as a direct activator of Cyp4f40 by influencing the PPARγ pathway. Through PPARγ modulation, Linoleic Acid enhances Cyp4f40 expression, triggering downstream events that amplify Cyp4f40 enzymatic activity, marking it as a direct activator. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A sc-200402B sc-200402C | 50 mg 500 mg 5 g 10 g | $69.00 $364.00 $2500.00 $4100.00 | 11 | |
Clozapine activates Cyp4f40 through PPARγ modulation. Operating as a PPARγ agonist, Clozapine stimulates Cyp4f40 expression, initiating a cascade of events that amplify Cyp4f40 enzymatic activity, solidifying its identity as a direct activator of Cyp4f40. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin acts as a direct activator of Cyp4f40 through PPARγ modulation. By functioning as a PPARγ agonist, Indomethacin enhances Cyp4f40 expression, initiating a series of events that amplify Cyp4f40 enzymatic activity, confirming its role as a direct activator. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate activates Cyp4f40 through PPARγ modulation. Operating as a PPARγ agonist, Bezafibrate boosts Cyp4f40 expression, initiating a cascade of events that amplify Cyp4f40 enzymatic activity, cementing its role as a direct activator of Cyp4f40. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643 serves as a direct activator of Cyp4f40 through PPARγ modulation. As a PPARγ agonist, WY-14643 enhances Cyp4f40 expression, initiating a series of events that amplify Cyp4f40 enzymatic activity, affirming its crucial role as a Cyp4f40 activator. | ||||||