Cyp4f40 Inhibitors
Cyp4f40 inhibitors are a class of chemical compounds designed to selectively target and inhibit the activity of the Cyp4f40 enzyme, a member of the cytochrome P450 superfamily. The Cyp4f40 enzyme plays a significant role in the oxidative metabolism of various lipophilic substrates, including long-chain fatty acids, eicosanoids, and other bioactive lipids. These substrates are crucial components of cellular signaling pathways, particularly those involved in inflammation, immune responses, and the regulation of vascular tone. The primary function of Cyp4f40 is to catalyze the hydroxylation of these substrates, a biochemical process that introduces an oxygen atom into the lipid molecule. This hydroxylation increases the solubility of these lipids, facilitating their subsequent metabolism, transport, or excretion. The enzyme is predominantly expressed in tissues such as the liver and kidneys, where it contributes to the regulation of lipid homeostasis and the detoxification of bioactive lipids, thereby maintaining overall physiological balance.
Inhibitors of Cyp4f40 are typically small molecules that interact directly with the enzyme's active site, effectively blocking its ability to bind and hydroxylate its natural substrates. These inhibitors may function by occupying the substrate-binding pocket, preventing the access of substrates to the catalytic site, or by inducing conformational changes that reduce the enzyme's catalytic efficiency. The design and development of Cyp4f40 inhibitors require a detailed understanding of the enzyme's structure, particularly the regions involved in substrate recognition and catalysis. By inhibiting Cyp4f40, researchers can explore the enzyme's specific role in lipid metabolism and its broader impact on related metabolic pathways. This includes understanding how the enzyme's activity influences the regulation of inflammation, immune responses, and vascular function. The study of Cyp4f40 inhibitors provides valuable insights into the enzyme's substrate specificity, its interactions with other metabolic enzymes, and its overall contribution to the complex network of biochemical processes that regulate lipid metabolism in the body. This research enhances our understanding of the diverse functions of cytochrome P450 enzymes and underscores their importance in maintaining metabolic homeostasis and the proper functioning of biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Aminobenzotriazole | 1614-12-6 | sc-200600 sc-200600A | 50 mg 100 mg | $61.00 $134.00 | 6 | |
1-Aminobenzotriazole acts as a direct inhibitor of Cyp4f40 by binding to its active site, disrupting the enzyme's catalytic function in the metabolism of fatty acids. This leads to a targeted inhibition of the protein, hindering its role in lipid homeostasis within various physiological structures. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
Sulconazole serves as a direct inhibitor of Cyp4f40, interfering with its heme group and thereby suppressing its role in the metabolism of arachidonic acid. This results in a specific inhibition of the protein, impacting its diverse expression in critical systems, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole acts as a direct inhibitor of Cyp4f40 by binding to its heme group, disrupting the enzyme's catalytic function in the metabolism of fatty acids. This leads to a specific inhibition of the target protein, influencing its expression within the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, impacting lipid homeostasis. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Miconazole functions as a direct inhibitor of Cyp4f40, binding to its heme group and interfering with the enzyme's catalytic function in the metabolism of fatty acids. This results in a targeted inhibition of the protein, affecting its diverse expression across critical physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole acts as a direct inhibitor of Cyp4f40 by disrupting the enzyme's heme group, hindering its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein, influencing its expression in various physiological structures such as the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, impacting lipid homeostasis. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $27.00 $56.00 $84.00 $343.00 | 2 | |
Imidazole acts as an indirect inhibitor of Cyp4f40 by influencing the PI3K/Akt signaling pathway. Through this modulation, the chemical disrupts the cellular processes that regulate the protein's activity, impacting its expression in critical physiological structures like the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, thereby influencing lipid homeostasis. | ||||||
Terbinafine | 91161-71-6 | sc-338609 | 100 mg | $560.00 | 1 | |
Terbinafine serves as a direct inhibitor of Cyp4f40, disrupting the enzyme's heme group and impeding its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein, impacting its expression in diverse physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, influencing lipid homeostasis. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Fluconazole serves as a direct inhibitor of Cyp4f40 by disrupting the enzyme's heme group, hindering its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein, influencing its expression in various physiological structures, such as the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, impacting lipid homeostasis. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-Methylumbelliferone indirectly inhibits Cyp4f40 by altering the expression of key genes in the xenobiotic metabolism pathway. This chemical interferes with the enzyme's substrate availability, impeding its catalytic activity. The altered substrate availability impacts the protein's expression in various physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, influencing lipid homeostasis. | ||||||