Cyp4f39 Activators
Cyp4f39, a vital member of the cytochrome P450 family, serves a pivotal role in cellular lipid homeostasis by catalyzing the ω-hydroxylation of fatty acids. This enzymatic process is crucial for the breakdown of long-chain fatty acids, contributing significantly to the regulation of lipid levels within various tissues. Predominantly expressed in the liver, Cyp4f39 plays a central role in maintaining the delicate balance of lipid metabolism, ensuring proper cellular function and energy homeostasis. Its substrate specificity towards fatty acids positions Cyp4f39 as a key player in the intricate network of metabolic pathways, particularly in the liver, where it participates in the detoxification and clearance of lipophilic compounds.
The activation of Cyp4f39 involves intricate cellular mechanisms centered around the modulation of the peroxisome proliferator-activated receptor alpha (PPARα) signaling pathway. Cyp4f39 is directly activated by specific chemicals that act as agonists for PPARα, a nuclear receptor intimately involved in the regulation of lipid metabolism. These chemicals engage PPARα, initiating a cascade of events that culminate in the upregulation of Cyp4f39 expression. Notable activators include dibutyl phthalate, gemfibrozil, clofibrate, fenofibrate, Wy-14643, triclosan, indomethacin, bezafibrate, WY-16115, cinnamic acid, perfluorooctanoic acid, and licochalcone A. The activation process involves the binding of these agonists to PPARα, which then translocates into the nucleus, forming a complex that modulates gene expression, including the upregulation of Cyp4f39. This enhanced expression ultimately amplifies Cyp4f39's enzymatic activity, contributing to its vital role in maintaining lipid homeostasis and supporting cellular functions essential for overall metabolic health. In summary, the intricate activation of Cyp4f39 through PPARα modulation showcases its indispensable role in lipid metabolism and positions it as a key regulator in maintaining cellular lipid homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Di-n-butyl phthalate | 84-74-2 | sc-257307 sc-257307A sc-257307B | 5 g 25 g 1 kg | $40.00 $51.00 $102.00 | 1 | |
Di-n-butyl phthalate induces Cyp4f39 activation by modulating PPARα. Acting as a PPARα agonist, it promotes Cyp4f39 transcription by binding to PPARα, initiating downstream events that culminate in enhanced Cyp4f39 expression, bolstering its enzymatic activity. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil activates Cyp4f39 through PPARα-mediated pathways. As a PPARα agonist, Gemfibrozil enhances Cyp4f39 expression by engaging PPARα, initiating a cascade of events that bolster the enzymatic activity of Cyp4f39, demonstrating its role as a direct activator. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate serves as a Cyp4f39 activator by modulating PPARα. Through PPARα agonism, Clofibrate triggers a signaling cascade that results in increased Cyp4f39 expression, positively influencing its enzymatic activity, establishing it as a direct activator of Cyp4f39. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate activates Cyp4f39 via PPARα modulation. Operating as a PPARα agonist, Fenofibrate stimulates Cyp4f39 expression by engaging PPARα, initiating a series of events that amplify Cyp4f39 enzymatic activity, confirming its role as a direct activator of Cyp4f39. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
Wy-14643 acts as a direct activator of Cyp4f39 through PPARα modulation. By functioning as a PPARα agonist, Wy-14643 enhances Cyp4f39 expression, orchestrating a cascade of events that augment Cyp4f39 enzymatic activity, signifying its pivotal role as a Cyp4f39 activator. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Triclosan activates Cyp4f39 through PPARα modulation. Operating as a PPARα agonist, Triclosan stimulates Cyp4f39 expression, initiating a series of events that amplify Cyp4f39 enzymatic activity, solidifying its identity as a direct activator of Cyp4f39. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin serves as a Cyp4f39 activator through PPARα modulation. Operating as a PPARα agonist, Indomethacin promotes Cyp4f39 expression, triggering a series of events that enhance Cyp4f39 enzymatic activity, establishing it as a direct activator of Cyp4f39. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate acts as a Cyp4f39 activator through PPARα modulation. By functioning as a PPARα agonist, Bezafibrate boosts Cyp4f39 expression, initiating a cascade of events that amplify Cyp4f39 enzymatic activity, cementing its role as a direct activator of Cyp4f39. | ||||||
trans-Cinnamic acid | 140-10-3 | sc-251283 sc-251283A sc-251283B | 100 g 500 g 2.5 kg | $31.00 $101.00 $403.00 | ||
Cinnamic Acid activates Cyp4f39 by influencing the ERK pathway. Through ERK pathway modulation, Cinnamic Acid enhances Cyp4f39 expression, triggering downstream events that amplify Cyp4f39 enzymatic activity, marking it as a direct activator of Cyp4f39. | ||||||
Pentadecafluorooctanoic acid | 335-67-1 | sc-250662 sc-250662A | 5 g 25 g | $49.00 $149.00 | ||
Perfluorooctanoic Acid serves as a direct activator of Cyp4f39 by influencing PPARα. As a PPARα agonist, Perfluorooctanoic Acid stimulates Cyp4f39 expression, initiating a cascade of events that amplify Cyp4f39 enzymatic activity, confirming its role as a Cyp4f39 activator. | ||||||