Cyp4f17 Inhibitors
Cyp4f17, a member of the cytochrome P450 family, plays a crucial role in the metabolism of fatty acids within various physiological structures. Its expression is diverse, involving critical systems such as the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems. The identified inhibitors exhibit specific mechanisms of action to suppress Cyp4f17 activity. Direct inhibitors such as 1-Aminobenzotriazole, Sulconazole, Clotrimazole, Miconazole, and Econazole interfere directly with the enzyme's heme group or active site, hindering its catalytic function in fatty acid metabolism.
Imidazole acts indirectly by modulating the PI3K/Akt and NF-κB signaling pathways, respectively, disrupting cellular processes regulating Cyp4f17. Terbinafine, Fluconazole, and Propiconazole directly inhibit the enzyme, interfering with its heme group or active site. Lastly, 4-Methylumbelliferone indirectly influences xenobiotic metabolism, reducing substrate availability for Cyp4f17. Understanding the intricate mechanisms of these inhibitors provides valuable insights into potential strategies for controlling Cyp4f17 activity in diverse physiological contexts. Further research is warranted to explore the implications of manipulating Cyp4f17 and its associated pathways for potential applications in metabolic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Aminobenzotriazole | 1614-12-6 | sc-200600 sc-200600A | 50 mg 100 mg | $61.00 $134.00 | 6 | |
1-Aminobenzotriazole acts as a direct inhibitor of Cyp4f17 by binding to its active site, disrupting the enzyme's catalytic function in the metabolism of fatty acids. This results in a targeted inhibition of the protein. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
Sulconazole serves as a direct inhibitor of Cyp4f17, interfering with its heme group and thereby suppressing its role in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole acts as a direct inhibitor of Cyp4f17 by binding to its heme group, disrupting the enzyme's catalytic function in the metabolism of fatty acids. This leads to a specific inhibition of the target protein. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Miconazole functions as a direct inhibitor of Cyp4f17, binding to its heme group and interfering with the enzyme's catalytic function in the metabolism of fatty acids. This results in a targeted inhibition of the protein. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole acts as a direct inhibitor of Cyp4f17 by disrupting the enzyme's heme group, hindering its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the target protein. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $27.00 $56.00 $84.00 $343.00 | 2 | |
Imidazole acts as an indirect inhibitor of Cyp4f17 by influencing the PI3K/Akt signaling pathway. Through this modulation, the chemical disrupts the cellular processes that regulate the protein's activity. | ||||||
Terbinafine | 91161-71-6 | sc-338609 | 100 mg | $560.00 | 1 | |
Terbinafine serves as a direct inhibitor of Cyp4f17, disrupting the enzyme's heme group and impeding its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the target protein. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Fluconazole serves as a direct inhibitor of Cyp4f17 by disrupting the enzyme's heme group, hindering its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the target protein. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-Methylumbelliferone indirectly inhibits Cyp4f17 by altering the expression of key genes in the xenobiotic metabolism pathway. This chemical interferes with the enzyme's substrate availability, impeding its catalytic activity. | ||||||