Cyp4f17 Activators
Cyp4f17 is a cytochrome P450 enzyme primarily involved in the metabolism of fatty acids and xenobiotics. Its activation is intricately linked to various cellular processes, with direct and indirect activators modulating its expression and enzymatic activity. The enzyme plays a crucial role in lipid metabolism, contributing to the breakdown of fatty acids and participating in detoxification processes. Direct activators such as Lithocholic Acid, Rifampicin, and Ursodeoxycholic Acid bind to Cyp4f17's regulatory region, promoting increased transcription and enzymatic activity. These activators showcase the specificity of chemical interactions with the enzyme. Indirect activators like Resveratrol and Dexamethasone influence Cyp4f17 through the modulation of Nrf2 and glucocorticoid receptor pathways, respectively, providing insights into the interconnected regulatory networks governing the enzyme's function.
The activation of Cyp4f17 reflects the integration of various signaling pathways and cellular responses. Bile acids, represented by Cholic Acid and Ursodeoxycholic Acid, directly stimulate Cyp4f17, emphasizing the enzyme's role in bile acid metabolism. Additionally, chemicals like Butyrate and 4-Phenylbutyrate indirectly upregulate Cyp4f17 by affecting cellular stress responses and unfolded protein pathways, highlighting the enzyme's involvement in maintaining cellular homeostasis. The diversity of activators and their specific mechanisms illustrate the complexity of Cyp4f17 regulation. Understanding these intricate connections provides a foundation for exploring the enzyme's role in cellular processes beyond its established functions in lipid metabolism and detoxification. Cyp4f17 activation is a dynamic process influenced by a range of chemicals, shedding light on the broader impact of these compounds on cellular functions related to metabolism and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in red wine, activates Cyp4f17 indirectly by modulating the Nrf2 pathway. It enhances Nrf2 translocation to the nucleus, leading to increased transcription of antioxidant genes. This heightened antioxidant response indirectly upregulates Cyp4f17, as it is involved in detoxification processes within the cell. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
Lithocholic Acid acts as a direct activator of Cyp4f17 by binding to its regulatory region. This bile acid stimulates Cyp4f17 expression, enhancing its enzymatic activity. The activation is specific, promoting Cyp4f17-mediated metabolism of lipids. The interaction between Lithocholic Acid and Cyp4f17 illustrates the direct modulation of the enzyme by a small molecule, resulting in increased lipid metabolism within the cellular context. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Sodium phenylbutyrate serves as an indirect activator of Cyp4f17 through unfolded protein response (UPR) modulation. By promoting the UPR pathway, this chemical influences the cellular stress response, subsequently upregulating Cyp4f17 expression. The connection lies in Cyp4f17's role in lipid metabolism, where UPR activation indirectly supports the enzyme's function by enhancing cellular adaptations to endoplasmic reticulum stress. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin acts as a direct activator of Cyp4f17 by binding to its regulatory region, promoting increased transcription. This antibiotic triggers a cascade of events that result in enhanced Cyp4f17 expression and activity. The activation is specific, supporting the role of Rifampicin in modulating Cyp4f17-mediated metabolic pathways, providing insights into the antibiotic's broader impact on cellular functions beyond its antimicrobial activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate serves as a direct activator of Cyp4f17, enhancing its expression and enzymatic activity. As a peroxisome proliferator-activated receptor alpha (PPARα) agonist, Fenofibrate directly binds to PPARα, leading to the transcriptional activation of Cyp4f17. This chemical illustrates a direct regulatory relationship, elucidating how Fenofibrate-induced PPARα activation specifically stimulates Cyp4f17, linking lipid metabolism and PPARα signaling in the cellular context. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone acts as an indirect activator of Cyp4f17 by modulating the glucocorticoid receptor (GR) pathway. By binding to GR, Dexamethasone triggers a cascade of events that indirectly upregulate Cyp4f17 expression and activity. This connection highlights the intricate interplay between glucocorticoid signaling and Cyp4f17 function, providing insights into the regulatory mechanisms influencing the enzyme's role in cellular processes related to lipid metabolism and inflammation. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Cholic Acid serves as a direct activator of Cyp4f17 by binding to its regulatory region, promoting increased transcription. This bile acid triggers a cascade of events that result in enhanced Cyp4f17 expression and activity. The activation is specific, supporting the role of Cholic Acid in modulating Cyp4f17-mediated metabolic pathways, providing insights into the broader impact of bile acids on cellular functions beyond their roles in digestion. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid serves as an indirect activator of Cyp4f17 through histone deacetylase (HDAC) inhibition. By blocking HDAC activity, Butyrate promotes histone acetylation, indirectly upregulating Cyp4f17 expression. This epigenetic modulation highlights the connection between Butyrate, HDAC inhibition, and the regulation of Cyp4f17-mediated metabolic pathways, offering insights into the broader impact of short-chain fatty acids on cellular functions beyond their roles in energy metabolism. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid serves as a direct activator of Cyp4f17 by binding to its regulatory region, promoting increased transcription. This vitamin A derivative triggers a cascade of events that result in enhanced Cyp4f17 expression and activity. The activation is specific, supporting the role of Retinoic Acid in modulating Cyp4f17-mediated metabolic pathways, providing insights into the broader impact of retinoids on cellular functions beyond their roles in development and homeostasis. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $52.00 $131.00 | 4 | |
Ursodeoxycholic Acid acts as a direct activator of Cyp4f17 by binding to its regulatory region, promoting increased transcription. This bile acid triggers a cascade of events that result in enhanced Cyp4f17 expression and activity. The activation is specific, supporting the role of Ursodeoxycholic Acid in modulating Cyp4f17-mediated metabolic pathways, providing insights into the broader impact of bile acids on cellular functions beyond their roles in digestion and cholesterol homeostasis. | ||||||