Molecular structure of 1-Aminobenzotriazole, CAS Number: 1614-12-6
1-Aminobenzotriazole (CAS 1614-12-6)
See product citations (6)
Alternate Names:
1-Abtz; benzotriazolylamine
Application:
1-Aminobenzotriazole is a suicide substrate for CYP-450 and chloroperoxidase
CAS Number:
1614-12-6
Purity:
≥98%
Molecular Weight:
134.14
Molecular Formula:
C6H6N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Aminobenzotriazole is a chemical compound characterized by its ability to inhibit cytochrome P450 enzymes, which are essential for the metabolism of many organic substances. This inhibition is due to the compound′s structure, which allows it to interact with the heme group of the cytochrome P450 enzymes, leading to the formation of stable complexes that halt the enzyme′s activity. 1-Aminobenzotriazole may be useful in studying in the metabolism and toxicological effects of various xenobiotics by modulating the enzymatic pathways involved. Its role in these studies helps in understanding how different substances are processed in biological systems and can affect enzyme functionality.
1-Aminobenzotriazole (CAS 1614-12-6) References
- 1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats. | Mugford, CA., et al. 1992. Fundam Appl Toxicol. 19: 43-9. PMID: 1397800
- In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology. | Mico, BA., et al. 1988. Biochem Pharmacol. 37: 2515-9. PMID: 3390214
- Acinetobacter baumannii, Klebsiella pneumoniae and Elizabethkingia miricola isolated from wastewater have biodegradable activity against fluoroquinolone. | Shaker, RAE., et al. 2022. World J Microbiol Biotechnol. 38: 187. PMID: 35972564
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes. | Crosby, SV., et al. 2022. Metabolites. 12: PMID: 36005645
- Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis. | Giamberardino, CD., et al. 2022. mBio. 13: e0234722. PMID: 36222509
- Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A. | Hassan, R., et al. 2022. Arch Toxicol. 96: 3349-3361. PMID: 36227364
- Ferulic acid is a putative surrender signal to stimulate programmed cell death in grapevines after infection with Neofusicoccum parvum. | Khattab, IM., et al. 2023. Plant Cell Environ. 46: 339-358. PMID: 36263963
- Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1. | Eltoukhy, A., et al. 2022. BMC Microbiol. 22: 294. PMID: 36482332
- Biotransformation of sulfamonomethoxine in a granular sludge system: Pathways and mechanisms. | Li, MY., et al. 2023. Chemosphere. 313: 137508. PMID: 36493889
- Impact of Extended and Combined Exposure of Bisphenol Compounds on Their Chromosome-Damaging Effect─Increased Potency and Shifted Mode of Action. | Yu, H. and Liu, Y. 2023. Environ Sci Technol. 57: 498-508. PMID: 36571243
- Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors. | Gu, H., et al. 2023. J Med Chem. 66: 473-490. PMID: 36576395
- Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection. | Tawaraishi, T., et al. 2023. J Med Chem. 66: 1221-1238. PMID: 36607408
- Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. | Mathews, JM., et al. 1985. J Pharmacol Exp Ther. 235: 186-90. PMID: 4045721
- Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. | Su, P., et al. 1998. Am J Physiol. 275: R426-38. PMID: 9688677
Inhibitor of:
ALDH1A2, CYP, CYP26, CYP26C1, Cyp2c55, Cyp2c68, CYP2J12, CYP2J7, CYP2J8, Cyp4f17, Cyp4f37, Cyp4f39, Cyp4f40, Enzyme, and FMO3.Substrate of:
CYP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Aminobenzotriazole, 50 mg | sc-200600 | 50 mg | $61.00 | |||
1-Aminobenzotriazole, 100 mg | sc-200600A | 100 mg | $134.00 |