CYP4A11 Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
17-ODYA (17-Octadecynoic acid) | 34450-18-5 | sc-200488 sc-200488C sc-200488A sc-200488B | 1 mg 5 mg 10 mg 100 mg | $42.00 $132.00 $214.00 $1438.00 | 9 | |
This fatty acid acts as a mechanism-based inhibitor of CYP4A11 by binding covalently to the active site of the enzyme, leading to its functional inhibition. | ||||||
DDMS | 206052-03-1 | sc-205289 sc-205289A | 1 mg 5 mg | $112.00 $510.00 | ||
1-Aminobenzotriazole derivative, DDMS, specifically inhibits CYP4A11 by forming a metabolic intermediate complex that inactivates the heme group essential for the enzyme's activity. | ||||||
HET-0016 | 339068-25-6 | sc-200673B sc-200673 sc-200673D sc-200673A sc-200673C | 1 mg 5 mg 10 mg 25 mg 100 mg | $24.00 $99.00 $147.00 $388.00 $1102.00 | 5 | |
As a selective inhibitor of 20-HETE synthesis, HET0016 directly inhibits CYP4A11 by competitively binding to its active site, preventing the enzyme from metabolizing arachidonic acid. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
As an imidazole antifungal agent, Miconazole inhibits CYP4A11 by binding to the heme component of the enzyme, thereby inhibiting its catalytic activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole is known to inhibit CYP4A11 by interacting with its heme iron, which is essential for the enzyme's metabolism of fatty acids. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole inhibits CYP4A11 by binding to its heme iron, similar to other azole inhibitors, leading to a decrease in enzyme activity. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
This compound inhibits CYP4A11 by binding to the heme group, similar to other azole derivatives, preventing the metabolism of the enzyme's natural substrates. | ||||||
Tioconazole | 65899-73-2 | sc-205864 sc-205864A | 1 g 5 g | $75.00 $118.00 | 1 | |
Tioconazole inhibits CYP4A11 by interacting with its heme group, thus inhibiting the enzyme′s activity. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole acts as an inhibitor of CYP4A11 by binding to the enzyme's heme iron, which is necessary for its catalytic function. | ||||||
6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride | 502656-68-0 | sc-205155 sc-205155A | 1 mg 5 mg | $38.00 $172.00 | ||
6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride exhibits distinctive interactions with CYP4A11, characterized by its imidazole moiety that facilitates coordination with heme iron. This compound's unique structural features promote specific electrostatic interactions, enhancing substrate binding. Its reaction kinetics suggest a rapid turnover rate, influenced by conformational flexibility, which may modulate enzyme activity and substrate specificity in metabolic pathways. | ||||||