DDMS (CAS 206052-03-1)

DDMS, or 2′,3′-Dideoxy-3′-thiomethylcytidine, with the CAS number 206052-03-1, is a synthetic analog of the nucleoside cytidine. It is characterized by the absence of hydroxyl groups at the 2′ and 3′ positions of the sugar moiety and the substitution of a thiomethyl group at the 3′ position. This structural modification renders DDMS a molecule of interest in the field of nucleic acid research, particularly in studies related to the inhibition of nucleic acid synthesis processes. The mechanism of action of DDMS primarily involves its incorporation into RNA or DNA during the synthesis phase, where it acts as a chain terminator. Due to its modified structure, once incorporated, DDMS prevents the addition of further nucleotides, effectively halting the elongation process of the nucleic acid chain. This property has been exploited in various non-clinical research settings to study the dynamics of nucleic acid synthesis and the potential regulatory mechanisms controlling these processes. Moreover, DDMS has been used to investigate the fidelity and mechanisms of various polymerases, as its incorporation can provide insights into the enzyme′s substrate specificity and reaction kinetics, contributing significantly to our understanding of genetic replication and transcription processes at a molecular level.