CYP2J8 Activators
CYP2J8, a member of the cytochrome P450 family, exhibits a diverse array of predicted enzymatic activities, including heme binding, isomerase, and monooxygenase functions. Positioned within the cytoplasm and intracellular membrane-bounded organelles, this enzyme plays a pivotal role in cellular processes such as the epoxygenase P450 pathway, linoleic acid metabolic process, and xenobiotic metabolism. Its functional significance lies in its contribution to the intricate transformation and detoxification of endogenous and exogenous compounds, fostering cellular homeostasis.
The activation of CYP2J8 is a complex interplay orchestrated by both direct and indirect mechanisms. Direct activators, exemplified by various chemical agents, engage specific regulatory elements, resulting in the upregulation of heme binding, isomerase, and monooxygenase activities directly within CYP2J8. These interactions directly enhance the enzymatic functions of CYP2J8, contributing to its crucial role in the epoxygenase P450 pathway and xenobiotic metabolism. On the other hand, indirect activators influence critical signaling pathways, particularly the Nrf2-ARE pathway, modulating the transcriptional machinery governing CYP2J8 expression. This nuanced regulation leads to increased expression and elevated enzymatic activities, accentuating the multifaceted role of CYP2J8 in cellular processes. The dynamic interplay of direct and indirect activators underscores the adaptability of CYP2J8 in responding to diverse cellular cues, emphasizing its intricate involvement in metabolic pathways essential for cellular function and resilience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
ATRA serves as a direct activator of CYP2J8, upregulating its heme binding, isomerase, and monooxygenase activities. This direct interaction enhances the enzymatic functions of CYP2J8, contributing to its role in the epoxygenase P450 pathway and xenobiotic metabolism. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin acts as a direct activator of CYP2J8, enhancing its isomerase and monooxygenase activities. This direct interaction promotes increased enzymatic activity, contributing to the linoleic acid metabolic process and xenobiotic metabolism facilitated by CYP2J8. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene serves as an indirect activator of CYP2J8 by modulating the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J8 transcription, leading to increased expression and elevated heme binding, isomerase, and monooxygenase activities, contributing to the linoleic acid metabolic process and xenobiotic metabolism. | ||||||
Clopidogrel | 113665-84-2 | sc-507403 | 1 g | $120.00 | 1 | |
Clopidogrel acts as a direct activator of CYP2J8, enhancing its monooxygenase activity. This direct interaction promotes increased enzymatic activity, contributing to the linoleic acid metabolic process and xenobiotic metabolism facilitated by CYP2J8. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane serves as an indirect activator of CYP2J8 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J8 transcription, leading to increased expression and elevated heme binding, isomerase, and monooxygenase activities, contributing to the linoleic acid metabolic process and xenobiotic metabolism. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone acts as a direct activator of CYP2J8, upregulating its heme binding, isomerase, and monooxygenase activities. This direct interaction enhances the enzymatic functions of CYP2J8, contributing to its role in the epoxygenase P450 pathway and xenobiotic metabolism. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein serves as a direct activator of CYP2J8, enhancing its isomerase and monooxygenase activities. This direct interaction promotes increased enzymatic activity, contributing to the linoleic acid metabolic process and xenobiotic metabolism facilitated by CYP2J8. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein serves as an indirect activator of CYP2J8 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J8 transcription, leading to increased expression and elevated heme binding, isomerase, and monooxygenase activities, contributing to the linoleic acid metabolic process and xenobiotic metabolism. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 acts as a direct activator of CYP2J8, upregulating its heme binding, isomerase, and monooxygenase activities. This direct interaction enhances the enzymatic functions of CYP2J8, contributing to its role in the epoxygenase P450 pathway and xenobiotic metabolism. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC serves as an indirect activator of CYP2J8 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J8 transcription, leading to increased expression and elevated heme binding, isomerase, and monooxygenase activities, contributing to the linoleic acid metabolic process and xenobiotic metabolism. | ||||||