CYP2J12 Activators
CYP2J12, a member of the cytochrome P450 family, possesses a diverse range of predicted enzymatic activities, including heme binding, isomerase, and monooxygenase activities. Positioned within the cytoplasm and intracellular membrane-bounded organelles, CYP2J12 is implicated in crucial cellular processes such as the epoxygenase P450 pathway, linoleic acid metabolic process, and xenobiotic metabolic process. These functionalities underscore its significance in the metabolism of endogenous and exogenous compounds, contributing to the intricate web of biochemical pathways within the cell. The primary function of CYP2J12 centers around its role as a catalyst in various metabolic processes. Its heme binding activity suggests involvement in electron transfer reactions, while the isomerase and monooxygenase activities hint at its capacity to catalyze structural transformations and oxygenation reactions, respectively. The participation of CYP2J12 in the epoxygenase P450 pathway is particularly noteworthy, as it is linked to the conversion of polyunsaturated fatty acids into bioactive epoxides, thereby modulating physiological responses. Additionally, its role in xenobiotic metabolism emphasizes its contribution to the detoxification and elimination of foreign substances. In the linoleic acid metabolic process, CYP2J12 may play a crucial role in the conversion of linoleic acid into biologically active derivatives, further highlighting its involvement in essential cellular functions.
The activation of CYP2J12 involves a sophisticated interplay of direct and indirect mechanisms. Direct activators directly engage with regulatory elements, fostering the upregulation of heme binding, isomerase, and monooxygenase activities. Meanwhile, indirect activators modulate specific signaling pathways, such as PPARα, PPARγ, and Nrf2-ARE, leading to enhanced transcription and subsequent elevation of CYP2J12 enzymatic functions. This intricate network of interactions highlights the versatility of CYP2J12 activation, underscoring its adaptability to diverse cellular cues. The involvement of endogenous molecules like epoxyeicosatrienoic acids (EETs) in a positive feedback loop further emphasizes the dynamic regulation of CYP2J12 activity. In conclusion, the functional versatility and regulation of CYP2J12 make it a crucial component in cellular metabolic processes, contributing to the maintenance of homeostasis and adaptation to environmental challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clopidogrel | 113665-84-2 | sc-507403 | 1 g | $120.00 | 1 | |
Clopidogrel serves as a direct activator of CYP2J12 by binding to its regulatory elements, promoting the upregulation of heme binding, isomerase, and monooxygenase activities. This interaction triggers a cascade leading to increased enzymatic activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate acts as an indirect activator of CYP2J12 through its modulation of the PPARα signaling pathway. Activation of PPARα enhances the transcription of CYP2J12, leading to increased expression and subsequent elevation of heme binding and monooxygenase activities. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin serves as an indirect activator of CYP2J12 through its influence on the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J12 transcription, leading to increased expression and elevated heme binding and monooxygenase activities. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts as an indirect activator of CYP2J12 through its modulation of the RAR signaling pathway. Activation of RAR enhances CYP2J12 transcription, leading to increased expression and elevated heme binding and monooxygenase activities. | ||||||
5′,6′-Epoxyeicosatrienoic acid | 87173-80-6 | sc-221066A sc-221066 sc-221066B sc-221066C | 25 µg 50 µg 100 µg 500 µg | $55.00 $100.00 $175.00 $551.00 | 4 | |
EETs serve as direct activators of CYP2J12 by participating in a positive feedback loop. As substrates for CYP2J12, EETs enhance the enzyme's own activity by promoting the epoxygenase pathway, leading to increased production of these activator molecules. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane acts as an indirect activator of CYP2J12 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J12 transcription, leading to increased expression and elevated heme binding and monooxygenase activities. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 serves as a direct activator of CYP2J12 by interacting with its regulatory elements, promoting the upregulation of heme binding, isomerase, and monooxygenase activities. This direct interaction triggers a cascade leading to increased enzymatic activity. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone acts as an indirect activator of CYP2J12 through its modulation of the PPARγ signaling pathway. Activation of PPARγ enhances the transcription of CYP2J12, leading to increased expression and subsequent elevation of heme binding and monooxygenase activities. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC acts as an indirect activator of CYP2J12 by influencing the Keap1-Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J12 transcription, leading to increased expression and elevated heme binding and monooxygenase activities. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene serves as an indirect activator of CYP2J12 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J12 transcription, leading to increased expression and elevated heme binding and monooxygenase activities. | ||||||